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- W2279436140 abstract "Osteosarcoma is a common, high malignant, and metastatic bone cancer. Amphiregulin (AREG) has been associated with cancer cellular activities. However, the effect of AREG on metastasis activity in human osteosarcoma cells has yet to be determined. We determined that AREG increases the expression of intercellular adhesion molecule-1 (ICAM-1) through PI3K/Akt signaling pathway via its interaction with the epidermal growth factor receptor, thus resulting in the enhanced cell migration of osteosarcoma. Furthermore, AREG stimulation increased the association of NF-κB to ICAM-1 promoter which then up-regulated ICAM-1 expression. Finally, we observed that shRNA silencing of AREG decreased osteosarcoma metastasis in vivo. Our findings revealed a relationship between osteosarcoma metastatic potential and AREG expression and the modulating effect of AREG on ICAM-1 expression." @default.
- W2279436140 created "2016-06-24" @default.
- W2279436140 creator A5059202056 @default.
- W2279436140 creator A5059398377 @default.
- W2279436140 creator A5084389502 @default.
- W2279436140 date "2015-10-19" @default.
- W2279436140 modified "2023-10-10" @default.
- W2279436140 title "Amphiregulin enhances intercellular adhesion molecule-1 expression and promotes tumor metastasis in human osteosarcoma" @default.
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- W2279436140 doi "https://doi.org/10.18632/oncotarget.5679" @default.
- W2279436140 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4747375" @default.
- W2279436140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26503469" @default.
- W2279436140 hasPublicationYear "2015" @default.
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