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• W2279487978 abstract "Lengthening (eccentric) contractions are known to induce skeletal muscle damage. Skeletal muscles of the dystrophin-deficient mdx mouse are especially sensitive to damage caused by lengthening contractions. Mild protocols of lengthening contractions, that cause no force decrement in normal mouse muscles, were found to cause a marked reduction in the maximal force produced by mdx muscles. The altered response of mdx muscles is considered to be due to sarcolemmal fragility, since no difference in force deficit after lengthening contractions was detected between mdx and control skinned fibers. We have developed an in vivo model to quantify the susceptibility of mdx mice muscles to eccentric contractions and showed a marked force decrease in the gastrocnemius of these animals. We generated a transgenic mouse in which an inducible constitutively active form of Akt1 can be expressed selectively in adult skeletal muscle. We found that activation of Akt is sufficient to induce rapid and functional skeletal muscle hypertrophy. We crossed mdx mice with Akt transgenic mice and show a clear protection against damage from lengthening contractions after 3 weeks of Akt activation. Surprisingly, this protection is not correlated to muscle hypertrophy and is independent on the mTOR-pathway since rapamycin-treatment doesn’t inhibit the protective effect of Akt.Protection against damage occurs on the mofibrillar level, most likely mitigated by an increase of utrophin leading to a reinforced cytoskeleton." @default.
• W2279487978 created "2016-06-24" @default.
• W2279487978 creator A5042616296 @default.
• W2279487978 date "2007-12-17" @default.
• W2279487978 modified "2023-09-27" @default.
• W2279487978 title "The effects of Akt overexpression in normal and dystrophic skeletal muscle" @default.
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