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• W2279553657 abstract "Research into topics surrounding “oxidative stress” and redox biology has a long tradition which can be traced back to the beginning of modern biochemistry at the turn of the Twentieth Century. As part of this chapter, we will follow the different strands of investigation which have come together in the 1960s and 1970s to carve out the distinct field of redox biology we know today. Whilst there is not one inventor or starting date of oxidative stress research, it is safe to consider the late 1970s and early 1980s as the time when the pre-paradigm phase of this research was transformed into a more distinct field of biochemistry with its very own concepts, methods and, above all, language. At this point, the paradigm of “oxidative stress” enters the scene, which has subsequently initiated and / or stimulated numerous individual threads of investigation. Despite its significant contribution to redox biology, this paradigm has been faced by a range of so-called ‘anomalies’ during the following decades and hence has been refined by various (auxiliary) hypotheses, and evolved into a modern concept of cellular redox regulation, which also embraces widespread oxidative cell signalling and adaptive processes. This evolutionary process has found its manifestation in the development of many new concepts, such as the one of the “Reactive Sulfur Species” (RSS) and the “cellular thiolstat”. Furthermore, it has exerted a major influence on the notion of “antioxidants”, which in parallel has developed from a basic idea of fighting oxidants with antioxidants to a more differentiated concept of redox modulation in the ill and elderly, as part of functional food, as a quality label for “healthy food” and, last but not least, as an access to new shores, such as nutri-(epi)genetics. In the end, the theme of oxidative stress and redox biology is a wide and open field with a long and fruitful past and a promising, bright future." @default.
• W2279553657 created "2016-06-24" @default.
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• W2279553657 date "2015-01-01" @default.
• W2279553657 modified "2023-10-16" @default.
• W2279553657 title "A Historical Perspective on Oxidative Stress and Intracellular Redox Control" @default.
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• W2279553657 doi "https://doi.org/10.1007/978-3-319-19096-9_1" @default.
• W2279553657 hasPublicationYear "2015" @default.
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