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- W2279574803 abstract "There have been endless queues in Samunge village, Loliondo, Arusha, of people waiting to drink from the cup of a retired evangelical Reverend. Most people believe in divine powers behind his treatment with herbal medicine. The medicine is an extract of a plant called Carissa edulis that contains, among many other components, lupeol, carissol, β-amyrin and oleuropein as active ingredients. In this study, the four compounds were docked in various enzymes and proteins that are also targeted by conventional drugs to treat some of the known diseases, which are claimed to be treated by the Reverend's cup. This study has revealed the above active ingredients bind to almost all of those targets, giving credit to claims that the herbal medicines cures many ailments. Diseases investigated include HIV/AIDS, Diabetes, Erectile dysfunction, hyperlipidemia and Herpes simplex and in all, components of Carissa edulis demonstrated strong interactions sometime even stronger than that of conventional drugs that work by binding to similar sites. Keywords: HIV/AIDS, Carissa edulis, Docking, Lupeol, Carissol, β-Amyrin Oleuropein, Erectile Dysfunction, Diabetes, Hyperlipideamia, Herbal medicine, Loliondo, Tanzania." @default.
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- W2279574803 date "2012-07-24" @default.
- W2279574803 modified "2023-09-27" @default.
- W2279574803 title "Molecular Modeling Approach in Explaining the Medicinal Properties of Carissa Edulis and the Treatment of Chronic Diseases, Including HIV/AIDS and Many Others by Reverend Ambilikile Mwasapile’s Herbal Portion" @default.
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