Matches in SemOpenAlex for { <https://semopenalex.org/work/W2279580203> ?p ?o ?g. }
- W2279580203 abstract "Approximately 10 % of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their highly conserved N-terminal domains that incorporate proline-glutamate (PE) and proline-proline-glutamate (PPE) signature motifs. They are hypothesised to be important virulence factors involved with host-pathogen interactions, but their high genetic variability and complexity of analysis means they are typically disregarded in genome studies. To elucidate the structure of these genes, 518 genomes from a diverse international collection of clinical isolates were de novo assembled. A further 21 reference M. tuberculosis complex genomes and long read sequence data were used to validate the approach. SNP analysis revealed that variation in the majority of the 168 pe/ppe genes studied was consistent with lineage. Several recombination hotspots were identified, notably pe_pgrs3 and pe_pgrs17. Evidence of positive selection was revealed in 65 pe/ppe genes, including epitopes potentially binding to major histocompatibility complex molecules. This, the first comprehensive study of the pe and ppe genes, provides important insight into M. tuberculosis diversity and has significant implications for vaccine development." @default.
- W2279580203 created "2016-06-24" @default.
- W2279580203 creator A5000019910 @default.
- W2279580203 creator A5002784988 @default.
- W2279580203 creator A5012009516 @default.
- W2279580203 creator A5012974929 @default.
- W2279580203 creator A5018951921 @default.
- W2279580203 creator A5020522864 @default.
- W2279580203 creator A5021239624 @default.
- W2279580203 creator A5021801489 @default.
- W2279580203 creator A5023281649 @default.
- W2279580203 creator A5026225819 @default.
- W2279580203 creator A5030902624 @default.
- W2279580203 creator A5036256577 @default.
- W2279580203 creator A5039884786 @default.
- W2279580203 creator A5040282103 @default.
- W2279580203 creator A5040431176 @default.
- W2279580203 creator A5042365397 @default.
- W2279580203 creator A5045920340 @default.
- W2279580203 creator A5046049983 @default.
- W2279580203 creator A5048799943 @default.
- W2279580203 creator A5056139536 @default.
- W2279580203 creator A5056485188 @default.
- W2279580203 creator A5062490980 @default.
- W2279580203 creator A5062640529 @default.
- W2279580203 creator A5072231287 @default.
- W2279580203 creator A5072410858 @default.
- W2279580203 creator A5077255083 @default.
- W2279580203 creator A5079123140 @default.
- W2279580203 creator A5079191353 @default.
- W2279580203 creator A5083758387 @default.
- W2279580203 creator A5088093413 @default.
- W2279580203 date "2016-02-29" @default.
- W2279580203 modified "2023-10-16" @default.
- W2279580203 title "Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages" @default.
- W2279580203 cites W1551684330 @default.
- W2279580203 cites W1985986410 @default.
- W2279580203 cites W1994939019 @default.
- W2279580203 cites W2003111456 @default.
- W2279580203 cites W2005203688 @default.
- W2279580203 cites W2006128966 @default.
- W2279580203 cites W2012473911 @default.
- W2279580203 cites W2015498428 @default.
- W2279580203 cites W2017376644 @default.
- W2279580203 cites W2019790854 @default.
- W2279580203 cites W2024116008 @default.
- W2279580203 cites W2040258241 @default.
- W2279580203 cites W2046765318 @default.
- W2279580203 cites W2054294323 @default.
- W2279580203 cites W2057212110 @default.
- W2279580203 cites W2058607113 @default.
- W2279580203 cites W2060276579 @default.
- W2279580203 cites W2066321034 @default.
- W2279580203 cites W2069290534 @default.
- W2279580203 cites W2072550492 @default.
- W2279580203 cites W2076972592 @default.
- W2279580203 cites W2081816898 @default.
- W2279580203 cites W2087793347 @default.
- W2279580203 cites W2098679236 @default.
- W2279580203 cites W2101099771 @default.
- W2279580203 cites W2101478678 @default.
- W2279580203 cites W2104760481 @default.
- W2279580203 cites W2104874810 @default.
- W2279580203 cites W2105329815 @default.
- W2279580203 cites W2107282968 @default.
- W2279580203 cites W2107772251 @default.
- W2279580203 cites W2108234281 @default.
- W2279580203 cites W2110150994 @default.
- W2279580203 cites W2110335151 @default.
- W2279580203 cites W2110949356 @default.
- W2279580203 cites W2111062185 @default.
- W2279580203 cites W2112463092 @default.
- W2279580203 cites W2115317782 @default.
- W2279580203 cites W2115501618 @default.
- W2279580203 cites W2120902911 @default.
- W2279580203 cites W2130530163 @default.
- W2279580203 cites W2133790733 @default.
- W2279580203 cites W2135408377 @default.
- W2279580203 cites W2135524542 @default.
- W2279580203 cites W2138474951 @default.
- W2279580203 cites W2142410038 @default.
- W2279580203 cites W2142739377 @default.
- W2279580203 cites W2153953403 @default.
- W2279580203 cites W2155645165 @default.
- W2279580203 cites W2159050264 @default.
- W2279580203 cites W2160969485 @default.
- W2279580203 cites W2161925679 @default.
- W2279580203 cites W2162581200 @default.
- W2279580203 cites W2166890773 @default.
- W2279580203 cites W2170565120 @default.
- W2279580203 cites W2171467729 @default.
- W2279580203 cites W2756006822 @default.
- W2279580203 doi "https://doi.org/10.1186/s12864-016-2467-y" @default.
- W2279580203 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4770551" @default.
- W2279580203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26923687" @default.
- W2279580203 hasPublicationYear "2016" @default.
- W2279580203 type Work @default.
- W2279580203 sameAs 2279580203 @default.
- W2279580203 citedByCount "60" @default.
- W2279580203 countsByYear W22795802032016 @default.