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- W2279582769 abstract "Purpose To review the literature surrounding the involvement of the endothelium and matrix metalloproteinases (MMP) in radiotherapy-induced gut toxicity (RIGT) and further elucidate its complex pathobiology. Results RIGT involves damage to the gastrointestinal mucosa and is associated with diarrhoea, pain, and rectal bleeding depending on the area of exposure. The mechanisms underpinning RIGT are complex and have not yet been elucidated. Members of the MMP family, particularly MMP-2 and -9, have recently been identified as being key markers in RIGT and chemotherapy-induced gut toxicity (CIGT). Furthermore, the microvasculature has long been implicated in the development of toxicities following both chemotherapy and radiotherapy, however, the mechanisms behind this are yet to be explored. Conclusions It is proposed that matrix metalloproteinases are key regulators of endothelial mediators, and may play a key role in inducing damage to intestinal microvasculature following radiotherapy." @default.
- W2279582769 created "2016-06-24" @default.
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- W2279582769 date "2016-02-26" @default.
- W2279582769 modified "2023-09-27" @default.
- W2279582769 title "Radiotherapy-induced gut toxicity: Involvement of matrix metalloproteinases and the intestinal microvasculature" @default.
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- W2279582769 doi "https://doi.org/10.3109/09553002.2016.1146830" @default.
- W2279582769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26917115" @default.
- W2279582769 hasPublicationYear "2016" @default.
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