Matches in SemOpenAlex for { <https://semopenalex.org/work/W2279585364> ?p ?o ?g. }
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- W2279585364 abstract "It has been 20years that the G protein-coupled estrogen receptor (GPER) was cloned as the orphan receptor GPR30 from multiple cellular sources, including vascular endothelial cells. Here, I will provide an overview of estrogen biology and the historical background leading to the discovery of rapid vascular estrogen signaling. I will also review the recent advances in the understanding of the mechanisms underlying GPER function, its role in physiology and disease, some of the currently available GPER-targeting drugs approved for clinical use such as SERMs (selective estrogen receptor modulators) and SERDs (selective estrogen receptor downregulators). Many of currently used drugs such as tamoxifen, raloxifene, or faslodex™/fulvestrant were discovered targeting GPER many years after they had been introduced to the clinics for entirely different purposes. This has important implications for the clinical use of these drugs and their modes of action, which I have termed 'reverse translational medicine'. In addition, environmental pollutants known as 'endocrine disruptors' have been found to bind to GPER. This article also discusses recent evidence in these areas as well as opportunities in translational clinical medicine and GPER research, including medical genetics, personalized medicine, prevention, and its theranostic use." @default.
- W2279585364 created "2016-06-24" @default.
- W2279585364 creator A5060993179 @default.
- W2279585364 date "2016-07-01" @default.
- W2279585364 modified "2023-10-10" @default.
- W2279585364 title "Not lost in translation: Emerging clinical importance of the G protein-coupled estrogen receptor GPER" @default.
- W2279585364 cites W1145404920 @default.
- W2279585364 cites W1514446981 @default.
- W2279585364 cites W1541753142 @default.
- W2279585364 cites W1551831696 @default.
- W2279585364 cites W1645757190 @default.
- W2279585364 cites W1654458964 @default.
- W2279585364 cites W1879486454 @default.
- W2279585364 cites W1939543107 @default.
- W2279585364 cites W1941062711 @default.
- W2279585364 cites W1958808161 @default.
- W2279585364 cites W1962720541 @default.
- W2279585364 cites W1963570942 @default.
- W2279585364 cites W1964153361 @default.
- W2279585364 cites W1966502355 @default.
- W2279585364 cites W1967990741 @default.
- W2279585364 cites W1968397178 @default.
- W2279585364 cites W1970358298 @default.
- W2279585364 cites W1970379862 @default.
- W2279585364 cites W1970760886 @default.
- W2279585364 cites W1971671660 @default.
- W2279585364 cites W1972086601 @default.
- W2279585364 cites W1976257390 @default.
- W2279585364 cites W1976678368 @default.
- W2279585364 cites W1981306061 @default.
- W2279585364 cites W1981467972 @default.
- W2279585364 cites W1982712540 @default.
- W2279585364 cites W1984948100 @default.
- W2279585364 cites W1985141838 @default.
- W2279585364 cites W1985941840 @default.
- W2279585364 cites W1986965597 @default.
- W2279585364 cites W1989852353 @default.
- W2279585364 cites W1990426958 @default.
- W2279585364 cites W1990563853 @default.
- W2279585364 cites W1992177227 @default.
- W2279585364 cites W1992293805 @default.
- W2279585364 cites W1994001086 @default.
- W2279585364 cites W1995857875 @default.
- W2279585364 cites W1996079534 @default.
- W2279585364 cites W1996732665 @default.
- W2279585364 cites W2001500298 @default.
- W2279585364 cites W2001507203 @default.
- W2279585364 cites W2002479315 @default.
- W2279585364 cites W2002738980 @default.
- W2279585364 cites W2004512161 @default.
- W2279585364 cites W2006109557 @default.
- W2279585364 cites W2011090984 @default.
- W2279585364 cites W2012644882 @default.
- W2279585364 cites W2015789469 @default.
- W2279585364 cites W2017886735 @default.
- W2279585364 cites W2022072580 @default.
- W2279585364 cites W2022880162 @default.
- W2279585364 cites W2024905084 @default.
- W2279585364 cites W2025138095 @default.
- W2279585364 cites W2026514054 @default.
- W2279585364 cites W2027025502 @default.
- W2279585364 cites W2031004019 @default.
- W2279585364 cites W2032006984 @default.
- W2279585364 cites W2033327841 @default.
- W2279585364 cites W2033845089 @default.
- W2279585364 cites W2034944794 @default.
- W2279585364 cites W2036551189 @default.
- W2279585364 cites W2036711488 @default.
- W2279585364 cites W2036913880 @default.
- W2279585364 cites W2037059323 @default.
- W2279585364 cites W2037621705 @default.
- W2279585364 cites W2037790468 @default.
- W2279585364 cites W2038933398 @default.
- W2279585364 cites W2042106728 @default.
- W2279585364 cites W2045050323 @default.
- W2279585364 cites W2046002743 @default.
- W2279585364 cites W2046157340 @default.
- W2279585364 cites W2047370704 @default.
- W2279585364 cites W2047968184 @default.
- W2279585364 cites W2048655519 @default.
- W2279585364 cites W2049116118 @default.
- W2279585364 cites W2049552065 @default.
- W2279585364 cites W2050652857 @default.
- W2279585364 cites W2051596977 @default.
- W2279585364 cites W2053406129 @default.
- W2279585364 cites W2054353107 @default.
- W2279585364 cites W2055546971 @default.
- W2279585364 cites W2055608506 @default.
- W2279585364 cites W2057156798 @default.
- W2279585364 cites W2058673224 @default.
- W2279585364 cites W2061167652 @default.
- W2279585364 cites W2061739720 @default.
- W2279585364 cites W2061747115 @default.
- W2279585364 cites W2062244421 @default.
- W2279585364 cites W2064116070 @default.
- W2279585364 cites W2064410014 @default.
- W2279585364 cites W2065785294 @default.
- W2279585364 cites W2065839239 @default.