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- W2279656743 abstract "Foot-and-mouth disease virus (FMDV) is the etiological agent of FMD, which affects cloven-hoofed animals. The pathophysiology of FMDV has not been fully understood and the evasion of host innate immune system is still unclear. Here, the FMDV non-structural protein 3A was identified as a negative regulator of virus-triggered IFN-β signaling pathway. Overexpression of the FMDV 3A inhibited Sendai virus-triggered activation of IRF3 and the expressions of RIG-I/MDA5. Transient transfection and co-immunoprecipitation experiments suggested that FMDV 3A interacts with RIG-I, MDA5 and VISA, which is dependent on the N-terminal 51 amino acids of 3A. Furthermore, 3A also inhibited the expressions of RIG-I, MDA5, and VISA by disrupting their mRNA levels. These results demonstrated that 3A inhibits the RLR-mediated IFN-β induction and uncovered a novel mechanism by which the FMDV 3A protein evades the host innate immune system." @default.
- W2279656743 created "2016-06-24" @default.
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- W2279656743 date "2016-02-17" @default.
- W2279656743 modified "2023-10-16" @default.
- W2279656743 title "Foot-and-mouth disease virus non-structural protein 3A inhibits the interferon-β signaling pathway" @default.
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- W2279656743 doi "https://doi.org/10.1038/srep21888" @default.
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