FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2279682227> ?p ?o ?g. }

• W2279682227 endingPage "1014" @default.
• W2279682227 startingPage "1005" @default.
• W2279682227 abstract "Objective To comprehensively assess published randomized peer-reviewed studies related to volatile agents used for sedation in intensive care unit (ICU) settings, with the hypothesis that volatile agents could reduce time to extubation in adult patients. Design Systematic review and meta-analysis of randomized trials. Setting Intensive care units. Participants Critically ill patients. Interventions None. Measurements and Main Results The BioMedCentral, PubMed, Embase, and Cochrane Central Register databases of clinical trials were searched systematically for studies on volatile agents used in the ICU setting. Articles were assessed by trained investigators, and divergences were resolved by consensus. Inclusion criteria included random allocation to treatment (volatile agents versus any intravenous comparator, with no restriction on dose or time of administration) in patients requiring mechanical ventilation in the ICU. Twelve studies with 934 patients were included in the meta-analysis. The use of halogenated agents reduced the time to extubation (standardized mean difference = –0.78 [–1.01 to –0.55] hours; p for effect<0.00001; p for heterogeneity = 0.18; I2 = 32% in 7 studies with 503 patients). Results for time to extubation were confirmed in all subanalyses (eg, medical and surgical patients) and sensitivity analyses. No differences in length of hospital stay, ICU stay, and mortality were recorded. Conclusions In this meta-analysis of randomized trials, volatile anesthetics reduced time to extubation in medical and surgical ICU patients. The results of this study should be confirmed by large and high-quality randomized controlled studies. To comprehensively assess published randomized peer-reviewed studies related to volatile agents used for sedation in intensive care unit (ICU) settings, with the hypothesis that volatile agents could reduce time to extubation in adult patients. Systematic review and meta-analysis of randomized trials. Intensive care units. Critically ill patients. None. The BioMedCentral, PubMed, Embase, and Cochrane Central Register databases of clinical trials were searched systematically for studies on volatile agents used in the ICU setting. Articles were assessed by trained investigators, and divergences were resolved by consensus. Inclusion criteria included random allocation to treatment (volatile agents versus any intravenous comparator, with no restriction on dose or time of administration) in patients requiring mechanical ventilation in the ICU. Twelve studies with 934 patients were included in the meta-analysis. The use of halogenated agents reduced the time to extubation (standardized mean difference = –0.78 [–1.01 to –0.55] hours; p for effect<0.00001; p for heterogeneity = 0.18; I2 = 32% in 7 studies with 503 patients). Results for time to extubation were confirmed in all subanalyses (eg, medical and surgical patients) and sensitivity analyses. No differences in length of hospital stay, ICU stay, and mortality were recorded. In this meta-analysis of randomized trials, volatile anesthetics reduced time to extubation in medical and surgical ICU patients. The results of this study should be confirmed by large and high-quality randomized controlled studies." @default.
• W2279682227 created "2016-06-24" @default.
• W2279682227 creator A5016891339 @default.
• W2279682227 creator A5020375239 @default.
• W2279682227 creator A5028927302 @default.
• W2279682227 creator A5068430114 @default.
• W2279682227 creator A5072968608 @default.
• W2279682227 creator A5082319371 @default.
• W2279682227 creator A5085853928 @default.
• W2279682227 creator A5088708752 @default.
• W2279682227 creator A5090690846 @default.
• W2279682227 date "2016-08-01" @default.
• W2279682227 modified "2023-09-30" @default.
• W2279682227 title "Volatile Agents in Medical and Surgical Intensive Care Units: A Meta-Analysis of Randomized Clinical Trials" @default.
• W2279682227 cites W1247553610 @default.
• W2279682227 cites W1497796578 @default.
• W2279682227 cites W1555856568 @default.
• W2279682227 cites W1561496887 @default.
• W2279682227 cites W1600401360 @default.
• W2279682227 cites W1966901000 @default.
• W2279682227 cites W1981572619 @default.
• W2279682227 cites W1984707399 @default.
• W2279682227 cites W1990788267 @default.
• W2279682227 cites W2000022948 @default.
• W2279682227 cites W2013431655 @default.
• W2279682227 cites W2020891266 @default.
• W2279682227 cites W2024500589 @default.
• W2279682227 cites W2036612048 @default.
• W2279682227 cites W2039765919 @default.
• W2279682227 cites W2040465000 @default.
• W2279682227 cites W2041441379 @default.
• W2279682227 cites W2051536796 @default.
• W2279682227 cites W2054763520 @default.
• W2279682227 cites W2055473184 @default.
• W2279682227 cites W2055475141 @default.
• W2279682227 cites W2064014695 @default.
• W2279682227 cites W2067722551 @default.
• W2279682227 cites W2073830685 @default.
• W2279682227 cites W2074167195 @default.
• W2279682227 cites W2075795136 @default.
• W2279682227 cites W2076813172 @default.
• W2279682227 cites W2086591138 @default.
• W2279682227 cites W2089182419 @default.
• W2279682227 cites W2106099121 @default.
• W2279682227 cites W2109616324 @default.
• W2279682227 cites W2127709547 @default.
• W2279682227 cites W2128287868 @default.
• W2279682227 cites W2129562049 @default.
• W2279682227 cites W2130271602 @default.
• W2279682227 cites W2131071626 @default.
• W2279682227 cites W2134833483 @default.
• W2279682227 cites W2137124394 @default.
• W2279682227 cites W2139146091 @default.
• W2279682227 cites W2152691108 @default.
• W2279682227 cites W2157319537 @default.
• W2279682227 cites W2165763416 @default.
• W2279682227 cites W2410574102 @default.
• W2279682227 cites W3191282401 @default.
• W2279682227 cites W43297903 @default.
• W2279682227 cites W79015887 @default.
• W2279682227 doi "https://doi.org/10.1053/j.jvca.2016.02.021" @default.
• W2279682227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27238433" @default.
• W2279682227 hasPublicationYear "2016" @default.
• W2279682227 type Work @default.
• W2279682227 sameAs 2279682227 @default.
• W2279682227 citedByCount "21" @default.
• W2279682227 countsByYear W22796822272016 @default.
• W2279682227 countsByYear W22796822272017 @default.
• W2279682227 countsByYear W22796822272018 @default.
• W2279682227 countsByYear W22796822272019 @default.
• W2279682227 countsByYear W22796822272021 @default.
• W2279682227 countsByYear W22796822272022 @default.
• W2279682227 countsByYear W22796822272023 @default.
• W2279682227 crossrefType "journal-article" @default.
• W2279682227 hasAuthorship W2279682227A5016891339 @default.
• W2279682227 hasAuthorship W2279682227A5020375239 @default.
• W2279682227 hasAuthorship W2279682227A5028927302 @default.
• W2279682227 hasAuthorship W2279682227A5068430114 @default.
• W2279682227 hasAuthorship W2279682227A5072968608 @default.
• W2279682227 hasAuthorship W2279682227A5082319371 @default.
• W2279682227 hasAuthorship W2279682227A5085853928 @default.
• W2279682227 hasAuthorship W2279682227A5088708752 @default.
• W2279682227 hasAuthorship W2279682227A5090690846 @default.
• W2279682227 hasConcept C126322002 @default.
• W2279682227 hasConcept C141071460 @default.
• W2279682227 hasConcept C168563851 @default.
• W2279682227 hasConcept C17744445 @default.
• W2279682227 hasConcept C177713679 @default.
• W2279682227 hasConcept C194828623 @default.
• W2279682227 hasConcept C199539241 @default.
• W2279682227 hasConcept C2776376669 @default.
• W2279682227 hasConcept C2776814716 @default.
• W2279682227 hasConcept C2777080012 @default.
• W2279682227 hasConcept C2779473830 @default.
• W2279682227 hasConcept C2987404301 @default.
• W2279682227 hasConcept C42219234 @default.
• W2279682227 hasConcept C535046627 @default.
• W2279682227 hasConcept C71924100 @default.

• next