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- W2279686021 abstract "Silastic vaginal rings impregnated with progesterone (P) or progesterone and estradiol (E) were used in nine women for thirty 21-day cycles to study the effect on ovarian function. The average daily rates of release of P and E from the rings were 2.2 mg/day and 220 microgram/day, respectively. In anovulatory treatment cycles the mean plasma level of P was 0.9 ng/ml. E levels fluctuated in the range seen in normally cycling women due to endogenous E production. In a menopausal woman the E levels increased to 50 to 100 pg/ml during treatment and FSH levels declined. Ovulation occurred in 18 (60%) of the treated cycles, and resulted in one pregnancy. Although the results rule out the use of these rings for contraceptive purposes, they indicate that at higher dosages the Silastic vaginal ring offers a mode of administration of natural steroids to be used in hormonal contraception.This study was conducted to determine whether a relatively low dose of P (progesterone) alone or in combination with estradiol (E) administered from silastic vaginal rings would suppress ovulation, thus providing a safe contraceptive form women. 9 healthy fertile women with regular menstrual cycles were studied for a total of 30 21-day cycles. 4 women used a ring with a P dose while the other 4 used the combination ring. 1 65 year old menopausal woman used both types of ring for 2 weeks. Venous blood samples were collected 2-3 times a week from the subjects and were analyzed for E, P, and FSH levels using radioimmunoassay and radioimmunosorbent technique. The average daily rate of release for P from the rings was 2.2 mg/day and 220 ug/day for E. Mean plasma level of P in anovulatory treatment cycle was 0.9 ng/ml. E levels fluctuated in the range seen in normal women because of endogenous E production. The E levels for the menopausal woman increased from 50 to 100 pg/ml during treatment. Ovulation was observed in 18 (60%) of the treated cycles, resulting in 1 pregnancy. The pregnancy which occurred in this series suggests that P does not provide the 'local' protective effect of synthetic gestagens used in low dose gestagen contraceptive pills. However, the pregnancy may also be attributed to the passage of spermatozoa 7 days after the ring was removed. Further studies should be done on P-releasing contraceptive rings." @default.
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- W2279686021 date "1978-12-01" @default.
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- W2279686021 title "Vaginal Progesterone for Contraception" @default.
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- W2279686021 doi "https://doi.org/10.1016/s0015-0282(16)43688-5" @default.
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