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• W2279752406 endingPage "L115" @default.
• W2279752406 startingPage "L107" @default.
• W2279752406 abstract "The effects of dexamethasone, a glucocorticoid analog, on interleukin 8 (IL-8) gene expression were studied in cultures of primary human tracheobronchial epithelial cells and an immortalized human bronchial epithelial cell line, HBE1 cells. Dexamethasone inhibited IL-8 mRNA and protein expression in a concentration- and time-dependent manner. The inhibition did not occur at the transcriptional level since both nuclear run-on activity and IL-8 promoter-reporter gene expression assay revealed no significant effect. Instead, there was a change in IL-8 mRNA stability in dexamethasone-treated cultures. Under actinomycin D treatment, IL-8 mRNA was quite stable in dexamethasone-depleted cultures, while in dexamethasone-pretreated cultures, IL-8 message was rapidly degraded within the first hour, then leveled off. When dexamethasone and actinomycin D were added simultaneously to dexamethasone-depleted cultures, IL-8 mRNA remained rather stable. When cycloheximide was used to inhibit new protein synthesis, dexamethasone-dependent inhibition was not observed. These results suggest that a posttranscriptional mechanism, which requires dexamethasone-dependent new protein synthesis, is involved in the regulation of IL-8 mRNA by dexamethasone in airway epithelial cells." @default.
• W2279752406 created "2016-06-24" @default.
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• W2279752406 date "2001-01-01" @default.
• W2279752406 modified "2023-09-26" @default.
• W2279752406 title "Mechanism of dexamethasone-mediated interleukin-8 gene suppression in cultured airway epithelial cells" @default.
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• W2279752406 doi "https://doi.org/10.1152/ajplung.2001.280.1.l107" @default.
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