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• W2279758515 abstract "Long non-coding RNAs (lncRNAs) are increasingly implicated as gene regulators and may ultimately be more numerous than protein-coding genes in the human genome. Despite large numbers of reported lncRNAs, reference annotations are likely incomplete due to their lower and tighter tissue-specific expression compared to mRNAs. An unexplored factor potentially confounding lncRNA identification is inter-individual expression variability. Here, we characterize lncRNA natural expression variability in human primary granulocytes.We annotate granulocyte lncRNAs and mRNAs in RNA-seq data from 10 healthy individuals, identifying multiple lncRNAs absent from reference annotations, and use this to investigate three known features (higher tissue-specificity, lower expression, and reduced splicing efficiency) of lncRNAs relative to mRNAs. Expression variability was examined in seven individuals sampled three times at 1- or more than 1-month intervals. We show that lncRNAs display significantly more inter-individual expression variability compared to mRNAs. We confirm this finding in two independent human datasets by analyzing multiple tissues from the GTEx project and lymphoblastoid cell lines from the GEUVADIS project. Using the latter dataset we also show that including more human donors into the transcriptome annotation pipeline allows identification of an increasing number of lncRNAs, but minimally affects mRNA gene number.A comprehensive annotation of lncRNAs is known to require an approach that is sensitive to low and tight tissue-specific expression. Here we show that increased inter-individual expression variability is an additional general lncRNA feature to consider when creating a comprehensive annotation of human lncRNAs or proposing their use as prognostic or disease markers." @default.
• W2279758515 created "2016-06-24" @default.
• W2279758515 creator A5000855496 @default.
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• W2279758515 creator A5046008529 @default.
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• W2279758515 creator A5076531332 @default.
• W2279758515 date "2016-01-29" @default.
• W2279758515 modified "2023-10-12" @default.
• W2279758515 title "Long non-coding RNAs display higher natural expression variation than protein-coding genes in healthy humans" @default.
• W2279758515 cites W1533942137 @default.
• W2279758515 cites W1602695373 @default.
• W2279758515 cites W1816176398 @default.
• W2279758515 cites W1968332563 @default.
• W2279758515 cites W1969836160 @default.
• W2279758515 cites W1970741980 @default.
• W2279758515 cites W1972440741 @default.
• W2279758515 cites W1977060570 @default.
• W2279758515 cites W1979906868 @default.
• W2279758515 cites W1986348806 @default.
• W2279758515 cites W1986705163 @default.
• W2279758515 cites W1995724539 @default.
• W2279758515 cites W1999746344 @default.
• W2279758515 cites W2006479497 @default.
• W2279758515 cites W2006936482 @default.
• W2279758515 cites W2017653670 @default.
• W2279758515 cites W2020541351 @default.
• W2279758515 cites W2021168471 @default.
• W2279758515 cites W2022199909 @default.
• W2279758515 cites W2024329298 @default.
• W2279758515 cites W2025943989 @default.
• W2279758515 cites W2026659598 @default.
• W2279758515 cites W2029919331 @default.
• W2279758515 cites W2030048096 @default.
• W2279758515 cites W2031017459 @default.
• W2279758515 cites W2036402097 @default.
• W2279758515 cites W2038234348 @default.
• W2279758515 cites W2038720677 @default.
• W2279758515 cites W2044806644 @default.
• W2279758515 cites W2049760108 @default.
• W2279758515 cites W2050819173 @default.
• W2279758515 cites W2056419701 @default.
• W2279758515 cites W2056933088 @default.
• W2279758515 cites W2058615001 @default.
• W2279758515 cites W2059191987 @default.
• W2279758515 cites W2064140451 @default.
• W2279758515 cites W2075320162 @default.
• W2279758515 cites W2077352904 @default.
• W2279758515 cites W2079588819 @default.
• W2279758515 cites W2079983771 @default.
• W2279758515 cites W2088069070 @default.
• W2279758515 cites W2088960792 @default.
• W2279758515 cites W2092467693 @default.
• W2279758515 cites W2092645079 @default.
• W2279758515 cites W2093404711 @default.
• W2279758515 cites W2094257363 @default.
• W2279758515 cites W2096237610 @default.
• W2279758515 cites W2096465161 @default.
• W2279758515 cites W2098188013 @default.
• W2279758515 cites W2100305481 @default.
• W2279758515 cites W2105349784 @default.
• W2279758515 cites W2105714972 @default.
• W2279758515 cites W2106948237 @default.
• W2279758515 cites W2107454957 @default.
• W2279758515 cites W2109001721 @default.
• W2279758515 cites W2109699478 @default.
• W2279758515 cites W2116593863 @default.
• W2279758515 cites W2119726708 @default.
• W2279758515 cites W2120597842 @default.
• W2279758515 cites W2125569948 @default.
• W2279758515 cites W2126475719 @default.
• W2279758515 cites W2129078669 @default.
• W2279758515 cites W2132015542 @default.
• W2279758515 cites W2134033103 @default.
• W2279758515 cites W2134625814 @default.
• W2279758515 cites W2134903961 @default.
• W2279758515 cites W2135532051 @default.
• W2279758515 cites W2136101247 @default.
• W2279758515 cites W2136550485 @default.
• W2279758515 cites W2140874466 @default.
• W2279758515 cites W2141831115 @default.
• W2279758515 cites W2142735201 @default.
• W2279758515 cites W2144137532 @default.
• W2279758515 cites W2153268494 @default.
• W2279758515 cites W2155623567 @default.
• W2279758515 cites W2156880688 @default.
• W2279758515 cites W2156925439 @default.
• W2279758515 cites W2158050409 @default.
• W2279758515 cites W2160333540 @default.
• W2279758515 cites W2164773184 @default.
• W2279758515 cites W2166810745 @default.
• W2279758515 cites W2169456326 @default.
• W2279758515 cites W2169769858 @default.
• W2279758515 cites W563719155 @default.
• W2279758515 doi "https://doi.org/10.1186/s13059-016-0873-8" @default.
• W2279758515 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4731934" @default.

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