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• W2279785896 abstract "Background and purpose To investigate the dose–response relation between the dose to the vagina and the patient-reported symptom ‘absence of vaginal elasticity’ and how time to follow-up influences this relation. Material and methods The study included 78 long-term gynecological cancer survivors treated between 1991 and 2003 with external beam radiation therapy. Of those, 24 experienced absence of vaginal elasticity. A normal tissue complication model is introduced that takes into account the influence of time to follow-up on the dose–response relation and the patient’s age. The best estimates of the dose–response parameters were calculated using Probit, Probit-Relative Seriality (RS) and Probit-time models. Log likelihood (LL) values and the Akaike Information Criterion (AIC) were used to evaluate the model fit. Results The dose–response parameters for ‘absence of vaginal elasticity’ according to the Probit and Probit-time models with the 68% Confidence Intervals (CI) were: LL = −39.8, D50 = 49.7 (47.2–52.4) Gy, γ50 = 1.40 (1.12–1.70) and LL = −37.4, D50 = 46.9 (43.5–50.9) Gy, γ50 = 1.81 (1.17–2.51) respectively. Conclusions The proposed model, which describes the influence of time to follow-up on the dose–response relation, fits our data best. Our data indicate that the steepness of the dose–response curve of the dose to the vagina and the symptom ‘absence of vaginal elasticity’ increases with time to follow-up, while D50 decreases." @default.
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• W2279785896 date "2016-09-01" @default.
• W2279785896 modified "2023-10-12" @default.
• W2279785896 title "Time-dependent dose–response relation for absence of vaginal elasticity after gynecological radiation therapy" @default.
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• W2279785896 doi "https://doi.org/10.1016/j.radonc.2016.02.013" @default.
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