Matches in SemOpenAlex for { <https://semopenalex.org/work/W227978700> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W227978700 abstract "Abstract : The purpose of phase (II) of the study was to investigate the effects of local wound management, specifically pulsatile lavage and closure through the zone of blast injury versus debridement above the zone of injury, on the prevalence and severity of ectopic bone formation following extremity blast amputation in a rat model. Thirty-six Sprague-Dawley rats underwent hindlimb blast amputation via a column of propelled water following detonation of a submerged explosive. There were three treatment groups (each n=12): Group 1 was irrigated with 1L of diluted chlorhexidine solution using pulsatile lavage and closed through the zone of blast injury; Group 2 underwent syringe irrigation and debridement above the zone of injury (ZOI) with through-knee amputation; and Group 3 underwent both pulsatile lavage and through-knee amputation. The control group (n=12) was irrigated with 250ml of chlorhexidine solution using a bulb syringe and minimal debridement of skin edges. The animals were followed with serial AP and lateral radiographs until euthanasia at 24 weeks, at which time HO severity was quantified as (0) absent, (1) mild, (2) moderate, or (3) severe, and HO type was qualified as contiguous with the residual limb or as distinct ectopic bony islands. No HO contiguous with the amputated residual limb occurred in any animal that underwent through-knee amputation above the zone of injury compared with a high prevalence of HO in the residual limbs closed through the zone of injury, suggesting that the local inflammatory milieu plays a critical and essential role in HO induction. Animals treated with pulsatile lavage developed more HO than animals amputated at a comparable level and irrigated with a bulb syringe; high-pressure irrigation appeared to potentiate the HO response and deserves further study." @default.
- W227978700 created "2016-06-24" @default.
- W227978700 creator A5038093002 @default.
- W227978700 creator A5041248865 @default.
- W227978700 creator A5043534173 @default.
- W227978700 date "2012-10-01" @default.
- W227978700 modified "2023-09-23" @default.
- W227978700 title "Heterotopic Ossification Following Extremity Blast Amputation: An Animal Model in the Sprague Dawley Rat" @default.
- W227978700 cites W1967256352 @default.
- W227978700 cites W2014465187 @default.
- W227978700 cites W2024850220 @default.
- W227978700 cites W2032759497 @default.
- W227978700 cites W2037219613 @default.
- W227978700 cites W2049533459 @default.
- W227978700 cites W2134575374 @default.
- W227978700 cites W2136773274 @default.
- W227978700 cites W2146698255 @default.
- W227978700 cites W53682016 @default.
- W227978700 cites W7734759 @default.
- W227978700 doi "https://doi.org/10.21236/ada581902" @default.
- W227978700 hasPublicationYear "2012" @default.
- W227978700 type Work @default.
- W227978700 sameAs 227978700 @default.
- W227978700 citedByCount "0" @default.
- W227978700 crossrefType "report" @default.
- W227978700 hasAuthorship W227978700A5038093002 @default.
- W227978700 hasAuthorship W227978700A5041248865 @default.
- W227978700 hasAuthorship W227978700A5043534173 @default.
- W227978700 hasConcept C126322002 @default.
- W227978700 hasConcept C141071460 @default.
- W227978700 hasConcept C2776204877 @default.
- W227978700 hasConcept C2778117688 @default.
- W227978700 hasConcept C2780650075 @default.
- W227978700 hasConcept C71924100 @default.
- W227978700 hasConcept C99508421 @default.
- W227978700 hasConceptScore W227978700C126322002 @default.
- W227978700 hasConceptScore W227978700C141071460 @default.
- W227978700 hasConceptScore W227978700C2776204877 @default.
- W227978700 hasConceptScore W227978700C2778117688 @default.
- W227978700 hasConceptScore W227978700C2780650075 @default.
- W227978700 hasConceptScore W227978700C71924100 @default.
- W227978700 hasConceptScore W227978700C99508421 @default.
- W227978700 hasLocation W2279787001 @default.
- W227978700 hasOpenAccess W227978700 @default.
- W227978700 hasPrimaryLocation W2279787001 @default.
- W227978700 hasRelatedWork W1990270102 @default.
- W227978700 hasRelatedWork W1999142014 @default.
- W227978700 hasRelatedWork W2012720002 @default.
- W227978700 hasRelatedWork W2054196782 @default.
- W227978700 hasRelatedWork W2167051636 @default.
- W227978700 hasRelatedWork W2301609197 @default.
- W227978700 hasRelatedWork W2366666323 @default.
- W227978700 hasRelatedWork W2368538328 @default.
- W227978700 hasRelatedWork W2431044021 @default.
- W227978700 hasRelatedWork W2559760157 @default.
- W227978700 isParatext "false" @default.
- W227978700 isRetracted "false" @default.
- W227978700 magId "227978700" @default.
- W227978700 workType "report" @default.