FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2279787803> ?p ?o ?g. }

• W2279787803 endingPage "43" @default.
• W2279787803 startingPage "31" @default.
• W2279787803 abstract "Nitroxyl (HNO) is currently a vasorelaxant of high interest, but as yet its mechanisms of action have not been fully elucidated. It is thought that HNO acts on K V channels to mediate vasorelaxation, and this has been shown in previous studies (Irvine et al , 2003; Favarolo & Kemp-Harper, 2009; Yuill et al , 2011). It has also been shown that high levels of glucose inhibit K V channels (Rainbow et al , 2006) so would inhibit HNO mediated relaxation. This study could provide further evidence of K V involvement of HNO mediated vasodilation. This study uses a temperature controlled organ bath with aortic ring preparations obtained from male Wistar rats, which were killed using approved schedule 1 methods. The section of aorta was connected to an isometric transducer linked to LabChart software. This was used to measure changes in tension in response to the addition of increasing concentrations of sodium nitroprusside (SNP) and Angeli’s salt. These tension changes were quantified and converted to percentage of total relaxation, and presented graphically. The results show that greater relaxation is achieved with Angeli’s salt at high concentrations (>1μM) under normal levels of glucose then under elevated levels of glucose, in both experiments with and without the HNO scavenger L-Cysteine. The lowest level of relaxation achieved was with Angeli’s salt with hydroxocobalamin (HxC) with high levels of glucose present. These results would appear to show that high glucose has the ability to inhibit HNO mediated relaxation. This would further indicate that K V channels are involved in vasorelaxation by HNO, which concurs with data from earlier studies (Irvine et al , 2003; Favarolo & Kemp-Harper, 2009; Yuill et al , 2011; Rainbow et al , 2006)." @default.
• W2279787803 created "2016-06-24" @default.
• W2279787803 creator A5034810389 @default.
• W2279787803 date "2012-01-01" @default.
• W2279787803 modified "2023-09-25" @default.
• W2279787803 title "Investigation of the vasorelaxant properties of Nitroxyl during altered glycaemic conditions" @default.
• W2279787803 cites W1488020481 @default.
• W2279787803 cites W1963543097 @default.
• W2279787803 cites W1966125535 @default.
• W2279787803 cites W1978344211 @default.
• W2279787803 cites W1982418097 @default.
• W2279787803 cites W2004342910 @default.
• W2279787803 cites W2006172842 @default.
• W2279787803 cites W2015677976 @default.
• W2279787803 cites W2018555496 @default.
• W2279787803 cites W2037731503 @default.
• W2279787803 cites W2043286086 @default.
• W2279787803 cites W2046930374 @default.
• W2279787803 cites W2071568997 @default.
• W2279787803 cites W2091198144 @default.
• W2279787803 cites W2096153581 @default.
• W2279787803 cites W2119910312 @default.
• W2279787803 cites W2126280238 @default.
• W2279787803 cites W2128189290 @default.
• W2279787803 cites W2128552232 @default.
• W2279787803 cites W2142900879 @default.
• W2279787803 cites W2151924608 @default.
• W2279787803 cites W2156678579 @default.
• W2279787803 cites W2159579272 @default.
• W2279787803 cites W2160677882 @default.
• W2279787803 cites W2171196215 @default.
• W2279787803 cites W2171905844 @default.
• W2279787803 cites W2258480142 @default.
• W2279787803 cites W2339821053 @default.
• W2279787803 hasPublicationYear "2012" @default.
• W2279787803 type Work @default.
• W2279787803 sameAs 2279787803 @default.
• W2279787803 citedByCount "0" @default.
• W2279787803 crossrefType "journal-article" @default.
• W2279787803 hasAuthorship W2279787803A5034810389 @default.
• W2279787803 hasConcept C120770815 @default.
• W2279787803 hasConcept C12554922 @default.
• W2279787803 hasConcept C126322002 @default.
• W2279787803 hasConcept C134018914 @default.
• W2279787803 hasConcept C178790620 @default.
• W2279787803 hasConcept C185592680 @default.
• W2279787803 hasConcept C2776029896 @default.
• W2279787803 hasConcept C2776142628 @default.
• W2279787803 hasConcept C2776619502 @default.
• W2279787803 hasConcept C2779610285 @default.
• W2279787803 hasConcept C2779750884 @default.
• W2279787803 hasConcept C2780829489 @default.
• W2279787803 hasConcept C519581460 @default.
• W2279787803 hasConcept C55493867 @default.
• W2279787803 hasConcept C71924100 @default.
• W2279787803 hasConcept C86803240 @default.
• W2279787803 hasConceptScore W2279787803C120770815 @default.
• W2279787803 hasConceptScore W2279787803C12554922 @default.
• W2279787803 hasConceptScore W2279787803C126322002 @default.
• W2279787803 hasConceptScore W2279787803C134018914 @default.
• W2279787803 hasConceptScore W2279787803C178790620 @default.
• W2279787803 hasConceptScore W2279787803C185592680 @default.
• W2279787803 hasConceptScore W2279787803C2776029896 @default.
• W2279787803 hasConceptScore W2279787803C2776142628 @default.
• W2279787803 hasConceptScore W2279787803C2776619502 @default.
• W2279787803 hasConceptScore W2279787803C2779610285 @default.
• W2279787803 hasConceptScore W2279787803C2779750884 @default.
• W2279787803 hasConceptScore W2279787803C2780829489 @default.
• W2279787803 hasConceptScore W2279787803C519581460 @default.
• W2279787803 hasConceptScore W2279787803C55493867 @default.
• W2279787803 hasConceptScore W2279787803C71924100 @default.
• W2279787803 hasConceptScore W2279787803C86803240 @default.
• W2279787803 hasIssue "2" @default.
• W2279787803 hasLocation W22797878031 @default.
• W2279787803 hasOpenAccess W2279787803 @default.
• W2279787803 hasPrimaryLocation W22797878031 @default.
• W2279787803 hasRelatedWork W1153643110 @default.
• W2279787803 hasRelatedWork W1977469444 @default.
• W2279787803 hasRelatedWork W1984610365 @default.
• W2279787803 hasRelatedWork W2058519479 @default.
• W2279787803 hasRelatedWork W2072282433 @default.
• W2279787803 hasRelatedWork W2088313877 @default.
• W2279787803 hasRelatedWork W2101319683 @default.
• W2279787803 hasRelatedWork W2108981007 @default.
• W2279787803 hasRelatedWork W2138192532 @default.
• W2279787803 hasRelatedWork W2171905844 @default.
• W2279787803 hasRelatedWork W2257077769 @default.
• W2279787803 hasRelatedWork W2362903292 @default.
• W2279787803 hasRelatedWork W2381351188 @default.
• W2279787803 hasRelatedWork W2432081240 @default.
• W2279787803 hasRelatedWork W2511043759 @default.
• W2279787803 hasRelatedWork W2884479330 @default.
• W2279787803 hasRelatedWork W3007581619 @default.
• W2279787803 hasRelatedWork W3148019062 @default.
• W2279787803 hasRelatedWork W3149446182 @default.
• W2279787803 hasVolume "5" @default.
• W2279787803 isParatext "false" @default.
• W2279787803 isRetracted "false" @default.

• next