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- W2279843283 endingPage "111" @default.
- W2279843283 startingPage "111" @default.
- W2279843283 abstract "<ns4:p>Hexameric helicases control both the initiation and the elongation phase of DNA replication. The toroidal structure of these enzymes provides an inherent challenge in the opening and loading onto DNA at origins, as well as the conformational changes required to exclude one strand from the central channel and activate DNA unwinding. Recently, high-resolution structures have not only revealed the architecture of various hexameric helicases but also detailed the interactions of DNA within the central channel, as well as conformational changes that occur during loading. This structural information coupled with advanced biochemical reconstitutions and biophysical methods have transformed our understanding of the dynamics of both the helicase structure and the DNA interactions required for efficient unwinding at the replisome.</ns4:p>" @default.
- W2279843283 created "2016-06-24" @default.
- W2279843283 creator A5088662521 @default.
- W2279843283 date "2016-01-27" @default.
- W2279843283 modified "2023-10-18" @default.
- W2279843283 title "Structural Mechanisms of Hexameric Helicase Loading, Assembly, and Unwinding" @default.
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