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- W2279846594 abstract "© 2009 by Taylor & Francis Group, LLC. This chapter describes a general model-based inversion scheme for recovering the concentrations of tissue chromophores from multiwavelength photoacoustic images. A diffusion-based finite element (FE) forward model of light transport is used to generate images of absorbed optical energy at different wavelengths as a function of chromophore concentrations. By iteratively adjusting the latter until the model output matches the measured multiwavelength images, a set of quantitative concentration maps that reveal the abundance of each chromophore can be obtained. The technique can be used to quantify physiologically important endogenous chromophores such as oxy (HbO2) and deoxyhemoglobin (HHb), or exogenous chromophores such as those used in molecular imaging. The aim of this chapter is to describe the theory and practice of this approach and is divided into two parts. In the first, we describe a simplified implementation in which the concentrations of multiple chromophores are recovered from experimental measurements of multi-wavelength time-resolved photoacoustic signals detected at 122a single spatial point in a tissue-mimicking phantom. In the second, the progress that has been made towards developing the computational methods required to solve the general problem of recovering maps of chromophore concentrations from photoacoustic images is described. First, the problem is set in context by considering what a photoacoustic image represents, the physical parameters that can be obtained from it, and the underlying hypothesis and methodology of the inversion scheme." @default.
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- W2279846594 date "2017-12-19" @default.
- W2279846594 modified "2023-09-26" @default.
- W2279846594 title "Quantitative Photoacoustic Imaging: Measurement of Absolute Chromophore Concentrations for Physiological and Molecular Imaging" @default.
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- W2279846594 doi "https://doi.org/10.1201/9781420059922-15" @default.
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