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- W2279871119 endingPage "2332" @default.
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- W2279871119 abstract "Extracellular vesicles released from cells are under intense investigation for their roles in cell–cell communication and cancer progression. However, individual vesicles have been difficult to probe as their small size renders them invisible by conventional light microscopy. However, as a consequence of their small size these vesicles possess highly curved lipid membranes that offer an unconventional target for curvature-sensing probes. In this article, we present a strategy for using peptide-based biosensors to detect highly curved membranes and the negatively charged membrane lipid phosphatidylserine, we delineate several assays used to validate curvature- and lipid-targeting mechanisms, and we explore potential applications in probing extracellular vesicles released from sources such as apoptotic cells, cancer cells, or activated platelets. J. Cell. Physiol. 231: 2327–2332, 2016. © 2016 Wiley Periodicals, Inc." @default.
- W2279871119 created "2016-06-24" @default.
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- W2279871119 date "2016-03-09" @default.
- W2279871119 modified "2023-09-29" @default.
- W2279871119 title "Lipid-Targeting Peptide Probes for Extracellular Vesicles" @default.
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- W2279871119 doi "https://doi.org/10.1002/jcp.25354" @default.
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