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- W2279935227 abstract "AbstractAmong oxygen free radicals, the hydroxyl radical OH° is considered to be the most toxic. It reacts very rapidly with virtually all molecules, leading to the formation of secondary free radicals and finally to oxidized end-products. OH° scavenger molecules protect against OH° toxicity. The aim of this work was to measure the reactivity of pentoxifylline (Ptx) with OH° and to determine its ability to protect a biological target, (lysozyme), from OH° inactivation. Pulse and gamma radiolysis were used respectively to obtain high single and stationary concentrations of OH°. We found that Ptx forms a transient radical with a rate constant of 7 X 109 M−1 s−1 and that this one disappears with a half-life of 25 µs. Lysozyme was inactivated by OH°, but was protected when Ptx was added to the solution. In comparison with other known scavengers, the following order of protection was obtained: thymine" @default.
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- W2279935227 date "2015-04-16" @default.
- W2279935227 modified "2023-09-25" @default.
- W2279935227 title "Protective Effect of Pentoxifylline Against Hydroxyl Radical-Induced Damage to Proteins" @default.
- W2279935227 doi "https://doi.org/10.1159/000419695" @default.
- W2279935227 hasPublicationYear "2015" @default.
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