Matches in SemOpenAlex for { <https://semopenalex.org/work/W2279951805> ?p ?o ?g. }
- W2279951805 endingPage "42" @default.
- W2279951805 startingPage "31" @default.
- W2279951805 abstract "Folates are essential in the intermediary metabolism of amino acids, synthesis of nucleotides and for maintaining methylation reactions. They are also linked to the production of neurotransmitters through GTP needed for the synthesis of tetrahydrobiopterin. During pregnancy, folate is needed for fetal development. Folate deficiency during this period has been linked to increased risk of neural tube defects. Disturbances of folate metabolism due to genetic abnormalities or the presence of autoantibodies to folate receptor alpha (FRα) can impair physiologic processes dependent on folate, resulting in a variety of developmental disorders including cerebral folate deficiency syndrome and autism spectrum disorders. Overall, adequate folate status has proven to be important during pregnancy as well as neurological development and functioning in neonates and children. Treatment with pharmacologic doses of folinic acid has led to reversal of some symptoms in many children diagnosed with cerebral folate deficiency syndrome and autism, especially in those positive for autoantibodies to FRα. Thus, as the brain continues to develop throughout fetal and infant life, it can be affected and become dysfunctional due to a defective folate transport contributing to folate deficiency. Treatment and prevention of these disorders can be achieved by identification of those at risk and supplementation with folinic acid." @default.
- W2279951805 created "2016-06-24" @default.
- W2279951805 creator A5029823185 @default.
- W2279951805 creator A5069815569 @default.
- W2279951805 creator A5078444506 @default.
- W2279951805 date "2016-07-01" @default.
- W2279951805 modified "2023-09-27" @default.
- W2279951805 title "The metabolic basis for developmental disorders due to defective folate transport" @default.
- W2279951805 cites W134004843 @default.
- W2279951805 cites W1521029440 @default.
- W2279951805 cites W1544175414 @default.
- W2279951805 cites W1577847097 @default.
- W2279951805 cites W1590031600 @default.
- W2279951805 cites W1597619535 @default.
- W2279951805 cites W1788126413 @default.
- W2279951805 cites W1813361552 @default.
- W2279951805 cites W1821797507 @default.
- W2279951805 cites W1901188053 @default.
- W2279951805 cites W1903089608 @default.
- W2279951805 cites W1915374051 @default.
- W2279951805 cites W1945836171 @default.
- W2279951805 cites W1952333224 @default.
- W2279951805 cites W1953849490 @default.
- W2279951805 cites W1958981537 @default.
- W2279951805 cites W1963776452 @default.
- W2279951805 cites W1968339300 @default.
- W2279951805 cites W1971804824 @default.
- W2279951805 cites W1972846387 @default.
- W2279951805 cites W1975717285 @default.
- W2279951805 cites W1977866186 @default.
- W2279951805 cites W1979745458 @default.
- W2279951805 cites W1980152507 @default.
- W2279951805 cites W1985614637 @default.
- W2279951805 cites W1990741742 @default.
- W2279951805 cites W1990935979 @default.
- W2279951805 cites W1992593557 @default.
- W2279951805 cites W1994383969 @default.
- W2279951805 cites W1995125290 @default.
- W2279951805 cites W1995967787 @default.
- W2279951805 cites W1997159656 @default.
- W2279951805 cites W1998318461 @default.
- W2279951805 cites W1999565580 @default.
- W2279951805 cites W2003078245 @default.
- W2279951805 cites W2003555906 @default.
- W2279951805 cites W2003813779 @default.
- W2279951805 cites W2004265420 @default.
- W2279951805 cites W2004511530 @default.
- W2279951805 cites W2008749969 @default.
- W2279951805 cites W2009193838 @default.
- W2279951805 cites W2016161820 @default.
- W2279951805 cites W2016386954 @default.
- W2279951805 cites W2019686818 @default.
- W2279951805 cites W2020297523 @default.
- W2279951805 cites W2023452084 @default.
- W2279951805 cites W202561933 @default.
- W2279951805 cites W2026641087 @default.
- W2279951805 cites W2027526997 @default.
- W2279951805 cites W2028776386 @default.
- W2279951805 cites W2028933698 @default.
- W2279951805 cites W2030780379 @default.
- W2279951805 cites W2032011914 @default.
- W2279951805 cites W2032360693 @default.
- W2279951805 cites W2033835940 @default.
- W2279951805 cites W2034109874 @default.
- W2279951805 cites W2035499872 @default.
- W2279951805 cites W2038435562 @default.
- W2279951805 cites W2051052717 @default.
- W2279951805 cites W2052211882 @default.
- W2279951805 cites W2057129148 @default.
- W2279951805 cites W2062445516 @default.
- W2279951805 cites W2063962637 @default.
- W2279951805 cites W2064381749 @default.
- W2279951805 cites W2066040173 @default.
- W2279951805 cites W2071076489 @default.
- W2279951805 cites W2071143931 @default.
- W2279951805 cites W2073185743 @default.
- W2279951805 cites W2073886406 @default.
- W2279951805 cites W2079159618 @default.
- W2279951805 cites W2082548421 @default.
- W2279951805 cites W2094049846 @default.
- W2279951805 cites W2094231638 @default.
- W2279951805 cites W2096158179 @default.
- W2279951805 cites W2097190507 @default.
- W2279951805 cites W2100706589 @default.
- W2279951805 cites W2102164375 @default.
- W2279951805 cites W2105524815 @default.
- W2279951805 cites W2109012926 @default.
- W2279951805 cites W2111359369 @default.
- W2279951805 cites W2113675370 @default.
- W2279951805 cites W2119226590 @default.
- W2279951805 cites W2119478454 @default.
- W2279951805 cites W2122713435 @default.
- W2279951805 cites W2126864090 @default.
- W2279951805 cites W2127010136 @default.
- W2279951805 cites W2129030385 @default.
- W2279951805 cites W2131351097 @default.
- W2279951805 cites W2133786616 @default.
- W2279951805 cites W2134018264 @default.