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- W2280081286 abstract "The nervous system plays a critical role in the regulation of animal body sizes. In Caenorhabditis elegans, an amine neurotransmitter, dopamine, is required for the tactile perception of food and food-dependent behavioral changes, while its role in development is unknown. In this study, we show that dopamine negatively regulates body size through a D2-like dopamine receptor, DOP-3, in C. elegans. Dopamine alters body size without affecting food intake or developmental rate. We also found that dopamine promotes egg-laying, although the regulation of body size by dopamine was not solely caused by this effect. Furthermore, dopamine negatively regulates body size through the suppression of signaling by octopamine and Gq-coupled octopamine receptors, SER-3 and SER-6. Our results demonstrate that dopamine and octopamine regulate the body size of C. elegans and suggest a potential role for perception in addition to ingestion of food for growth." @default.
- W2280081286 created "2016-06-24" @default.
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- W2280081286 date "2016-04-01" @default.
- W2280081286 modified "2023-10-02" @default.
- W2280081286 title "Dopamine regulates body size in Caenorhabditis elegans" @default.
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- W2280081286 doi "https://doi.org/10.1016/j.ydbio.2016.02.021" @default.
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