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• W2280091719 abstract "Conventionally, it is believed that the fraction of orally administered drugs absorbed from the intestine (Fa) and intestinal availability (Fg) are independently determined by the apical membrane permeation and intestinal metabolism, respectively. However, the validity of this belief has not been well discussed, and Fa and Fg are often used without careful definition. In this review, Fa and Fg are mathematically described based on their definitions under the linear kinetics of metabolism and transport. Even considering with different models, intestinal metabolic enzymes such as cytochrome P450 3A affected both Fa and Fg, whereas apical efflux transporters including P-glycoprotein had no influence on Fg at least under the linear condition. To determine whether Fa and Fg calculated using different clinical methods are identical, empirical Fa and Fg were mathematically described based on “feces method” and “grapefruit juice method” and compared with their definitions. Fa and Fg obtained by the feces method corresponded with their definitions whereas the grapefruit juice method provided smaller Fa and larger Fg particularly for dual substrates of P-glycoprotein and cytochrome P450 3A with low membrane permeability. Our analyses suggest that the definitions and calculation methods of Fa and Fg should be considered when we intend to separately determine these values." @default.
• W2280091719 created "2016-06-24" @default.
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• W2280091719 date "2016-02-01" @default.
• W2280091719 modified "2023-10-02" @default.
• W2280091719 title "Explication of Definitional Description and Empirical Use of Fraction of Orally Administered Drugs Absorbed From the Intestine (F a ) and Intestinal Availability (F g ): Effect of P-glycoprotein and CYP3A on F a and F g" @default.
• W2280091719 cites W113583849 @default.
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• W2280091719 doi "https://doi.org/10.1016/j.xphs.2015.11.005" @default.
• W2280091719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26869410" @default.
• W2280091719 hasPublicationYear "2016" @default.
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