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- W2280106471 abstract "Commentary on: Tuot DS, Lin F, Shlipak MG, et al. Potential impact of prescribing metformin according to eGFR rather than serum creatinine. Diabetes Care 2015;38:2059–67.[OpenUrl][1][Abstract/FREE Full Text][2]Metformin is the only oral antidiabetic drug shown to improve cardiovascular outcomes. A common clinical conundrum facing practitioners while using metformin is the potential risk of lactic acidosis (LA) which has a high mortality rate. Hence, according to the product information, metformin has several contraindications including renal impairment. However, recent studies have questioned some of these contraindications. In particular it has been suggested that the US Food and Drug Administration (FDA) recommendation to prescribe metformin based on serum creatinine (SCr) is overly conservative and may preclude many patients from taking metformin.1 The study by Tout et al investigated the impact of prescribing metformin based on SCr versus the estimated glomerular filtration rate (eGFR) … [1]: {openurl}?query=rft.jtitle%253DDiabetes%2BCare%26rft_id%253Dinfo%253Adoi%252F10.2337%252Fdc15-0542%26rft_id%253Dinfo%253Apmid%252F26307607%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=diacare&resid=38/11/2059&atom=%2Febmed%2F21%2F2%2F68.atom" @default.
- W2280106471 created "2016-06-24" @default.
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- W2280106471 date "2016-01-19" @default.
- W2280106471 modified "2023-09-27" @default.
- W2280106471 title "Prescribing of metformin based on estimated GFR rather than serum creatinine expands the eligible population and is likely safe" @default.
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- W2280106471 doi "https://doi.org/10.1136/ebmed-2015-110351" @default.
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