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- W2280133456 abstract "The synthesis and degradation of poly(ADP-ribose) is a rapid response to DNA damage [1, 2]. The focus of our recent studies has been to investigate the role of this metabolism in cellular responses to DNA damage, including cell death, mutagenesis, and malignant transformation. All of these biological responses to DNA damage are interrelated with DNA repair mechanisms, however, the relationships are poorly understood. We describe here recent studies in the in vitro transformation model, the C3H10T1/2 cell line. This cell line has been utilized extensively for quantitative studies of chemical carcinogenesis, mutational induction of ouabain resistance, and DNA repair. We have used inhibitors of ADP-ribosylation reactions to examine the possible involvement of poly(ADP-ribose) metabolism in responses of C3H10T1/2 cells to N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) treatment." @default.
- W2280133456 created "2016-06-24" @default.
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- W2280133456 date "1985-01-01" @default.
- W2280133456 modified "2023-09-25" @default.
- W2280133456 title "ADP-Ribosylation Reactions in Biological Responses to DNA Damage" @default.
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- W2280133456 doi "https://doi.org/10.1007/978-3-642-70589-2_36" @default.
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