Matches in SemOpenAlex for { <https://semopenalex.org/work/W2280147998> ?p ?o ?g. }
- W2280147998 endingPage "2807" @default.
- W2280147998 startingPage "2796" @default.
- W2280147998 abstract "Anti-neoplastic drugs used for cancer treatment often produce damage to healthy cells, leading to severe side effects in patients undergoing chemotherapy. The encapsulation of these agents in nanoparticles reduces the adverse side effects of conventional chemotherapy on healthy tissues. Such nanoparticles, considered as drug delivery vehicles, are diverse and include micelles, liposomes, dendrimers, nanocapsules, nanospheres and others. Polymeric micelles have been widely researched as nanocarriers for hydrophobic drugs. They can be designed to have increased stability and blood circulation time, as well as binding specificity to certain receptors overexpressed on the surface of cancer cells. Once these drug-encapsulating nanoparticles reach the tumor site, an external stimulus, such as ultrasound, can be used to spatially and temporally trigger drug release.This review paper focuses on the recent advances of cancer drug delivery systems employing polymeric micelles and ultrasound. An extensive literature review was performed mainly using PubMed. The introduction explains how nanocarriers are related to chemotherapy and the several modalities of use for this application. Afterwards, the review focuses on polymeric micelles used for drug delivery, their advantages and disadvantages. Subsequently, the physics of ultrasound is briefly reviewed, as well as the way it interacts with polymeric micelles to trigger the delivery of the drug transported by these nanocarriers. The following section focuses on targeting, discussing the several ways by which the nanoparticles can be directed to the target cells, and there deliver their cargo. Finally, a selection of relevant in vitro and in vivo studies, as well as clinical trials, is presented and discussed.Although there are still several research studies to be performed before the combination of micelles and ultrasound can enter clinical trials, the future of controlled delivery using this drug delivery system is promising as a way to reduce the mortality and morbidity of cancer and the noxious side effects of conventional chemotherapy." @default.
- W2280147998 created "2016-06-24" @default.
- W2280147998 creator A5007137768 @default.
- W2280147998 creator A5071308282 @default.
- W2280147998 creator A5075064291 @default.
- W2280147998 creator A5084026877 @default.
- W2280147998 date "2016-05-10" @default.
- W2280147998 modified "2023-10-01" @default.
- W2280147998 title "Drug Delivery Systems Based on Polymeric Micelles and Ultrasound: A Review" @default.
- W2280147998 cites W1555022612 @default.
- W2280147998 cites W1835935525 @default.
- W2280147998 cites W1964069216 @default.
- W2280147998 cites W1966434591 @default.
- W2280147998 cites W1966473157 @default.
- W2280147998 cites W1969169693 @default.
- W2280147998 cites W1969929756 @default.
- W2280147998 cites W1975071763 @default.
- W2280147998 cites W1975639006 @default.
- W2280147998 cites W1980901248 @default.
- W2280147998 cites W1981281909 @default.
- W2280147998 cites W1981998676 @default.
- W2280147998 cites W1983742493 @default.
- W2280147998 cites W1984556018 @default.
- W2280147998 cites W1985859113 @default.
- W2280147998 cites W1989261448 @default.
- W2280147998 cites W1989569827 @default.
- W2280147998 cites W1990444855 @default.
- W2280147998 cites W1990455420 @default.
- W2280147998 cites W1990641613 @default.
- W2280147998 cites W1993683005 @default.
- W2280147998 cites W1993895985 @default.
- W2280147998 cites W1995980440 @default.
- W2280147998 cites W1996193027 @default.
- W2280147998 cites W1998371839 @default.
- W2280147998 cites W1998464224 @default.
- W2280147998 cites W2002516695 @default.
- W2280147998 cites W2002975193 @default.
- W2280147998 cites W2003151318 @default.
- W2280147998 cites W2004432931 @default.
- W2280147998 cites W2005931776 @default.
- W2280147998 cites W2007037818 @default.
- W2280147998 cites W2013287766 @default.
- W2280147998 cites W2013765163 @default.
- W2280147998 cites W2016156919 @default.
- W2280147998 cites W2017532125 @default.
- W2280147998 cites W2018038198 @default.
- W2280147998 cites W2022432344 @default.
- W2280147998 cites W2025508675 @default.
- W2280147998 cites W2034051916 @default.
- W2280147998 cites W2035183350 @default.
- W2280147998 cites W2036640151 @default.
- W2280147998 cites W2037048276 @default.
- W2280147998 cites W2038526454 @default.
- W2280147998 cites W2038807714 @default.
- W2280147998 cites W2039834489 @default.
- W2280147998 cites W2040692743 @default.
- W2280147998 cites W2041066195 @default.
- W2280147998 cites W2041759339 @default.
- W2280147998 cites W2046528901 @default.
- W2280147998 cites W2046772999 @default.
- W2280147998 cites W2052994843 @default.
- W2280147998 cites W2054684716 @default.
- W2280147998 cites W2056083287 @default.
- W2280147998 cites W2056136031 @default.
- W2280147998 cites W2057627932 @default.
- W2280147998 cites W2057632167 @default.
- W2280147998 cites W2060882819 @default.
- W2280147998 cites W2061106944 @default.
- W2280147998 cites W2065429247 @default.
- W2280147998 cites W2068892913 @default.
- W2280147998 cites W2069379904 @default.
- W2280147998 cites W2070198605 @default.
- W2280147998 cites W2070672521 @default.
- W2280147998 cites W2071968656 @default.
- W2280147998 cites W2072337063 @default.
- W2280147998 cites W2072997205 @default.
- W2280147998 cites W2073645274 @default.
- W2280147998 cites W2075095534 @default.
- W2280147998 cites W2078027484 @default.
- W2280147998 cites W2079263230 @default.
- W2280147998 cites W2081855427 @default.
- W2280147998 cites W2082093834 @default.
- W2280147998 cites W2083348233 @default.
- W2280147998 cites W2084831115 @default.
- W2280147998 cites W2089645494 @default.
- W2280147998 cites W2090143546 @default.
- W2280147998 cites W2092029860 @default.
- W2280147998 cites W2093442802 @default.
- W2280147998 cites W2093856523 @default.
- W2280147998 cites W2094567694 @default.
- W2280147998 cites W2095510701 @default.
- W2280147998 cites W2099797949 @default.
- W2280147998 cites W2102449174 @default.
- W2280147998 cites W2104524915 @default.
- W2280147998 cites W2106787323 @default.
- W2280147998 cites W2108339776 @default.
- W2280147998 cites W2120377744 @default.
- W2280147998 cites W2126319786 @default.