FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2280346314> ?p ?o ?g. }

• W2280346314 endingPage "366" @default.
• W2280346314 startingPage "355" @default.
• W2280346314 abstract "Prion diseases involve the conversion of the endogenous cellular prion protein, PrP(C), into a misfolded infectious isoform, PrP(Sc). Several functions have been attributed to PrP(C), and its role has also been investigated in the olfactory system. PrP(C) is expressed in both the olfactory bulb (OB) and olfactory epithelium (OE) and the nasal cavity is an important route of transmission of diseases caused by prions. Moreover, Prnp(-/-) mice showed impaired behavior in olfactory tests. Given the high PrP(C) expression in OE and its putative role in olfaction, we screened a mouse OE cDNA library to identify novel PrP(C)-binding partners. Ten different putative PrP(C) ligands were identified, which were involved in functions such as cellular proliferation and apoptosis, cytoskeleton and vesicle transport, ubiquitination of proteins, stress response, and other physiological processes. In vitro binding assays confirmed the interaction of PrP(C) with STIP1 homology and U-Box containing protein 1 (Stub1) and are reported here for the first time. Stub1 is a co-chaperone with ubiquitin E3-ligase activity, which is associated with neurodegenerative diseases characterized by protein misfolding and aggregation. Physiological and pathological implications of PrP(C)-Stub1 interaction are under investigation. The PrP(C)-binding proteins identified here are not exclusive to the OE, suggesting that these interactions may occur in other tissues and play general biological roles. These data corroborate the proposal that PrP(C) is part of a multiprotein complex that modulates several cellular functions and provide a platform for further studies on the physiological and pathological roles of prion protein." @default.
• W2280346314 created "2016-06-24" @default.
• W2280346314 creator A5002253361 @default.
• W2280346314 creator A5040777809 @default.
• W2280346314 creator A5044379474 @default.
• W2280346314 creator A5054943208 @default.
• W2280346314 creator A5067923948 @default.
• W2280346314 creator A5072490965 @default.
• W2280346314 creator A5072867594 @default.
• W2280346314 creator A5087045544 @default.
• W2280346314 creator A5089347334 @default.
• W2280346314 date "2015-08-28" @default.
• W2280346314 modified "2023-10-12" @default.
• W2280346314 title "Identification of novel putative-binding proteins for cellular prion protein and a specific interaction with the STIP1 homology and U-Box-containing protein 1" @default.
• W2280346314 cites W1581222088 @default.
• W2280346314 cites W1605149529 @default.
• W2280346314 cites W1892858239 @default.
• W2280346314 cites W1970545697 @default.
• W2280346314 cites W1971140605 @default.
• W2280346314 cites W1990689284 @default.
• W2280346314 cites W1993222068 @default.
• W2280346314 cites W2003696769 @default.
• W2280346314 cites W2014043099 @default.
• W2280346314 cites W2017501471 @default.
• W2280346314 cites W2020258831 @default.
• W2280346314 cites W2021208608 @default.
• W2280346314 cites W2022714892 @default.
• W2280346314 cites W2024256697 @default.
• W2280346314 cites W2040969605 @default.
• W2280346314 cites W2049125266 @default.
• W2280346314 cites W2066992841 @default.
• W2280346314 cites W2078662153 @default.
• W2280346314 cites W2086999805 @default.
• W2280346314 cites W2095001137 @default.
• W2280346314 cites W2097462807 @default.
• W2280346314 cites W2104852035 @default.
• W2280346314 cites W2110029042 @default.
• W2280346314 cites W2110913851 @default.
• W2280346314 cites W2118732215 @default.
• W2280346314 cites W2119616506 @default.
• W2280346314 cites W2126762966 @default.
• W2280346314 cites W2127486078 @default.
• W2280346314 cites W2130567524 @default.
• W2280346314 cites W2147987476 @default.
• W2280346314 cites W2158243096 @default.
• W2280346314 cites W2166647667 @default.
• W2280346314 cites W2324660492 @default.
• W2280346314 cites W2381343259 @default.
• W2280346314 cites W2406794861 @default.
• W2280346314 cites W4213393524 @default.
• W2280346314 cites W4240506612 @default.
• W2280346314 doi "https://doi.org/10.1080/19336896.2015.1075347" @default.
• W2280346314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4964867" @default.
• W2280346314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26237451" @default.
• W2280346314 hasPublicationYear "2015" @default.
• W2280346314 type Work @default.
• W2280346314 sameAs 2280346314 @default.
• W2280346314 citedByCount "4" @default.
• W2280346314 countsByYear W22803463142017 @default.
• W2280346314 countsByYear W22803463142020 @default.
• W2280346314 countsByYear W22803463142022 @default.
• W2280346314 crossrefType "journal-article" @default.
• W2280346314 hasAuthorship W2280346314A5002253361 @default.
• W2280346314 hasAuthorship W2280346314A5040777809 @default.
• W2280346314 hasAuthorship W2280346314A5044379474 @default.
• W2280346314 hasAuthorship W2280346314A5054943208 @default.
• W2280346314 hasAuthorship W2280346314A5067923948 @default.
• W2280346314 hasAuthorship W2280346314A5072490965 @default.
• W2280346314 hasAuthorship W2280346314A5072867594 @default.
• W2280346314 hasAuthorship W2280346314A5087045544 @default.
• W2280346314 hasAuthorship W2280346314A5089347334 @default.
• W2280346314 hasBestOaLocation W22803463141 @default.
• W2280346314 hasConcept C104317684 @default.
• W2280346314 hasConcept C1292079 @default.
• W2280346314 hasConcept C134459356 @default.
• W2280346314 hasConcept C153911025 @default.
• W2280346314 hasConcept C169760540 @default.
• W2280346314 hasConcept C25602115 @default.
• W2280346314 hasConcept C27740335 @default.
• W2280346314 hasConcept C2780496858 @default.
• W2280346314 hasConcept C529278444 @default.
• W2280346314 hasConcept C53345823 @default.
• W2280346314 hasConcept C55493867 @default.
• W2280346314 hasConcept C86339819 @default.
• W2280346314 hasConcept C86803240 @default.
• W2280346314 hasConcept C95444343 @default.
• W2280346314 hasConceptScore W2280346314C104317684 @default.
• W2280346314 hasConceptScore W2280346314C1292079 @default.
• W2280346314 hasConceptScore W2280346314C134459356 @default.
• W2280346314 hasConceptScore W2280346314C153911025 @default.
• W2280346314 hasConceptScore W2280346314C169760540 @default.
• W2280346314 hasConceptScore W2280346314C25602115 @default.
• W2280346314 hasConceptScore W2280346314C27740335 @default.
• W2280346314 hasConceptScore W2280346314C2780496858 @default.
• W2280346314 hasConceptScore W2280346314C529278444 @default.
• W2280346314 hasConceptScore W2280346314C53345823 @default.
• W2280346314 hasConceptScore W2280346314C55493867 @default.
• W2280346314 hasConceptScore W2280346314C86339819 @default.

• next