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- W2280392257 abstract "The aim of our study was to assess the effects of dirlotapide on metabolic disorders in obese insulin resistant dogs. Dirlotapide is a MTP inhibitor that should promote weight loss by lowering fat absorption. Obese dogs were treated with placebo or dirlotapide for 21 wk. Food intake and body weight (BW) were recorded. Prior to and at the end of the treatment period, body condition score (BCS), insulin sensitivity (IS), plasma leptin and ghréline, and adiponectin mRNA expression were measured. BW and BCS did not change in placebo-treated dogs, whereas they were lower in dirlotapide-treated dogs. During the treatment period, food intake was higher (+4 %) than previously in placebo-treated dogs, whereas it was lower in dirlotapide-treated dogs. Basal insulinemia did not change in either group. Basal glycemia increased in placebo-treated dogs, while it was not affected by the dirlotapide treatment. IS did not change in placebo-treated dogs, whereas it increased in dirlotapide-treated animals. Plasma leptin and ghrelin levels were lower at the end of the dirlotapide treatment period. Adiponectin mRNA levels were higher at the end of the dirlotapide treatment. The lower BW and BCS at the end of the dirlotapide treatment period are consistent with lower leptin level, and higher adiponectin expression. That could have resulted from the lower food intake, and could account for the improvement in insulin sensitivity." @default.
- W2280392257 created "2016-06-24" @default.
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- W2280392257 date "2010-04-01" @default.
- W2280392257 modified "2023-09-23" @default.
- W2280392257 title "Dirlotapide improves body condition and insulin sensitivity in obese insulin resistant dogs" @default.
- W2280392257 doi "https://doi.org/10.1096/fasebj.24.1_supplement.725.8" @default.
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