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• W2280456961 abstract "Background/Aims: Propofol is widely used for sedation during endoscopy. Because propofol may cause hepatic encephalopathy, hemodynamic compromise, and respiratory depression, cautious use is required in patients with liver cirrhosis. We evaluated the safety and efficacy of propofol in compensated cirrhosis during endoscopic examination. Methods: Thirty-nine cirrhotic patients (19 and 20 cases of Child Pugh classes A and B, respectively) and 56 control subjects were included. The initial dose of propofol (40 mg) was increased by 20-mg increments until moderate sedation was achieved. The number connection test, flapping tremor test, blood pressure, heart rate, oxygen saturation, liver enzymes, and prothrombin time were evaluated before and after endoscopy. Results: No significant change was observed in any parameter compared to baseline in either group. The mean dose of propofol was significantly lower in cirrhotic versus control subjects (49.7±15.8 versus 65.0±17.9 mg, respectively; p" @default.
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• W2280456961 date "2008-11-01" @default.
• W2280456961 modified "2023-09-27" @default.
• W2280456961 title "Safety and efficacy of propofol for sedative endoscopy in patients with compensated liver cirrhosis" @default.
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