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- W2280490150 endingPage "80" @default.
- W2280490150 startingPage "63" @default.
- W2280490150 abstract "Neurological disorders - disorders of the brain, spine and associated nerves - are a leading contributor to global disease burden with a shockingly large associated economic cost. Various treatment approaches - pharmaceutical medication, device-based therapy, physiotherapy, surgical intervention, among others - have been explored to alleviate the resulting extent of human suffering. In recent years, gene therapy using viral vectors - encoding a therapeutic gene or inhibitory RNA into a gutted viral capsid and supplying it to the nervous system - has emerged as a clinically viable option for therapy of brain disorders. In this Review, we provide an overview of the current state and advances in the field of viral vector-mediated gene therapy for neurological disorders. Vector tools and delivery methods have evolved considerably over recent years, with the goal of providing greater and safer genetic access to the central nervous system. Better etiological understanding of brain disorders has concurrently led to identification of improved therapeutic targets. We focus on the vector technology, as well as preclinical and clinical progress made thus far for brain cancer and various neurodegenerative and neurometabolic disorders, and point out the challenges and limitations that accompany this new medical modality. Finally, we explore the directions that neurological gene therapy is likely to evolve towards in the future. This article is part of the Special Issue entitled Beyond small molecules for neurological disorders." @default.
- W2280490150 created "2016-06-24" @default.
- W2280490150 creator A5011401538 @default.
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- W2280490150 creator A5059573074 @default.
- W2280490150 creator A5064371575 @default.
- W2280490150 creator A5065454360 @default.
- W2280490150 date "2017-07-01" @default.
- W2280490150 modified "2023-10-16" @default.
- W2280490150 title "Viral vectors for therapy of neurologic diseases" @default.
- W2280490150 cites W115026875 @default.
- W2280490150 cites W1526704928 @default.
- W2280490150 cites W1558140404 @default.
- W2280490150 cites W1606662412 @default.
- W2280490150 cites W171436837 @default.
- W2280490150 cites W1776329700 @default.
- W2280490150 cites W1813590465 @default.
- W2280490150 cites W1824457652 @default.
- W2280490150 cites W1832822495 @default.
- W2280490150 cites W1873651958 @default.
- W2280490150 cites W1876029662 @default.
- W2280490150 cites W1902159756 @default.
- W2280490150 cites W1918258073 @default.
- W2280490150 cites W192711870 @default.
- W2280490150 cites W1961744561 @default.
- W2280490150 cites W1966374792 @default.
- W2280490150 cites W1966513242 @default.
- W2280490150 cites W1967044395 @default.
- W2280490150 cites W1967242914 @default.
- W2280490150 cites W1967843179 @default.
- W2280490150 cites W1968713059 @default.
- W2280490150 cites W1969271703 @default.
- W2280490150 cites W1971116733 @default.
- W2280490150 cites W1971643509 @default.
- W2280490150 cites W1974109622 @default.
- W2280490150 cites W1974317715 @default.
- W2280490150 cites W1977239997 @default.
- W2280490150 cites W1978221944 @default.
- W2280490150 cites W1978350886 @default.
- W2280490150 cites W1979294690 @default.
- W2280490150 cites W1980044002 @default.
- W2280490150 cites W1981877907 @default.
- W2280490150 cites W1981906938 @default.
- W2280490150 cites W1983924189 @default.
- W2280490150 cites W1983981470 @default.
- W2280490150 cites W1986419128 @default.
- W2280490150 cites W1986744301 @default.
- W2280490150 cites W1986816614 @default.
- W2280490150 cites W1986980701 @default.
- W2280490150 cites W1987114379 @default.
- W2280490150 cites W1987200082 @default.
- W2280490150 cites W1987208997 @default.
- W2280490150 cites W1988387373 @default.
- W2280490150 cites W1988658787 @default.
- W2280490150 cites W1988960349 @default.
- W2280490150 cites W1989720524 @default.
- W2280490150 cites W1991390602 @default.
- W2280490150 cites W1991711092 @default.
- W2280490150 cites W1992491142 @default.
- W2280490150 cites W1993439119 @default.
- W2280490150 cites W1994390268 @default.
- W2280490150 cites W1994710975 @default.
- W2280490150 cites W1996619801 @default.
- W2280490150 cites W1996634559 @default.
- W2280490150 cites W1996706043 @default.
- W2280490150 cites W1996788258 @default.
- W2280490150 cites W1997034660 @default.
- W2280490150 cites W1997814051 @default.
- W2280490150 cites W1997887168 @default.
- W2280490150 cites W1998290936 @default.
- W2280490150 cites W2000809016 @default.
- W2280490150 cites W2003456064 @default.
- W2280490150 cites W2003934533 @default.
- W2280490150 cites W2006920577 @default.
- W2280490150 cites W2008017799 @default.
- W2280490150 cites W2009078306 @default.
- W2280490150 cites W2009586398 @default.
- W2280490150 cites W2009787193 @default.
- W2280490150 cites W2010668151 @default.
- W2280490150 cites W2013503540 @default.
- W2280490150 cites W2014128251 @default.
- W2280490150 cites W2014850190 @default.
- W2280490150 cites W2015527284 @default.
- W2280490150 cites W2017210877 @default.
- W2280490150 cites W2017760748 @default.
- W2280490150 cites W2024102509 @default.
- W2280490150 cites W2024191529 @default.
- W2280490150 cites W2024421579 @default.
- W2280490150 cites W2025185410 @default.
- W2280490150 cites W2026584056 @default.
- W2280490150 cites W2026673655 @default.
- W2280490150 cites W2028033234 @default.
- W2280490150 cites W2029645617 @default.
- W2280490150 cites W2030588597 @default.
- W2280490150 cites W2032084713 @default.
- W2280490150 cites W2033005054 @default.
- W2280490150 cites W2033767465 @default.