Matches in SemOpenAlex for { <https://semopenalex.org/work/W2280491652> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2280491652 endingPage "46" @default.
- W2280491652 startingPage "36" @default.
- W2280491652 abstract "Patients from a poly-drug abuse treatment program with a history of sedative-hypnotic abuse were titrated with secobarbital, their alleged drug of choice, to a minimal state of toxicity consisting of nystagmus, drowsiness, ataxia, and slurred speech. Volunteer control subjects underwent the same titration procedure. Blood level determinations were made, and several pharmacokinetic parameters were estimated in order to determine the nature and degree of tolerance in the patient population. The patients tolerated a titration dose which was slightly, but significantly. higher than that tolerated by the control group. Cellular tolerance could be demonstrated in terms of higher blood levels determined at 7.0 hr after the last dose but not at the onset of toxicity. A significantly greater β-phase disposition constant and significantly smaller area under the curve per dose in the patient population suggested the contribution of drug disposition tolerance. Statistical comparisons of these parameters were made between several subgroups of the patient population. The patients indicating a higher frequency of sedative abuse did not differ from their patient counterparts. Those patients presenting with positive screens for barbiturates on admission provided similar results except for an apparently higher volume of distribution. Patients indicating concurrent alcohol use did not differ from the overall patient population; those also using amphetamines showed no sign of tolerance or increased elimination and were indistinguishable from control subjects." @default.
- W2280491652 created "2016-06-24" @default.
- W2280491652 creator A5009316715 @default.
- W2280491652 creator A5025022677 @default.
- W2280491652 creator A5035051859 @default.
- W2280491652 creator A5040471122 @default.
- W2280491652 creator A5080218692 @default.
- W2280491652 date "1978-01-01" @default.
- W2280491652 modified "2023-09-23" @default.
- W2280491652 title "Pharmacokinetic studies on tolerance to sedative-hypnotics in a poly-drug abuse population; I. Secobarbital" @default.
- W2280491652 doi "https://doi.org/10.1002/cpt197823136" @default.
- W2280491652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/618709" @default.
- W2280491652 hasPublicationYear "1978" @default.
- W2280491652 type Work @default.
- W2280491652 sameAs 2280491652 @default.
- W2280491652 citedByCount "4" @default.
- W2280491652 countsByYear W22804916522012 @default.
- W2280491652 crossrefType "journal-article" @default.
- W2280491652 hasAuthorship W2280491652A5009316715 @default.
- W2280491652 hasAuthorship W2280491652A5025022677 @default.
- W2280491652 hasAuthorship W2280491652A5035051859 @default.
- W2280491652 hasAuthorship W2280491652A5040471122 @default.
- W2280491652 hasAuthorship W2280491652A5080218692 @default.
- W2280491652 hasConcept C112705442 @default.
- W2280491652 hasConcept C139254425 @default.
- W2280491652 hasConcept C2776755955 @default.
- W2280491652 hasConcept C2776768635 @default.
- W2280491652 hasConcept C2777327472 @default.
- W2280491652 hasConcept C2777602617 @default.
- W2280491652 hasConcept C2779985140 @default.
- W2280491652 hasConcept C2780035454 @default.
- W2280491652 hasConcept C2780930544 @default.
- W2280491652 hasConcept C2908647359 @default.
- W2280491652 hasConcept C2910067630 @default.
- W2280491652 hasConcept C42219234 @default.
- W2280491652 hasConcept C6557445 @default.
- W2280491652 hasConcept C71924100 @default.
- W2280491652 hasConcept C86803240 @default.
- W2280491652 hasConcept C98274493 @default.
- W2280491652 hasConcept C99454951 @default.
- W2280491652 hasConceptScore W2280491652C112705442 @default.
- W2280491652 hasConceptScore W2280491652C139254425 @default.
- W2280491652 hasConceptScore W2280491652C2776755955 @default.
- W2280491652 hasConceptScore W2280491652C2776768635 @default.
- W2280491652 hasConceptScore W2280491652C2777327472 @default.
- W2280491652 hasConceptScore W2280491652C2777602617 @default.
- W2280491652 hasConceptScore W2280491652C2779985140 @default.
- W2280491652 hasConceptScore W2280491652C2780035454 @default.
- W2280491652 hasConceptScore W2280491652C2780930544 @default.
- W2280491652 hasConceptScore W2280491652C2908647359 @default.
- W2280491652 hasConceptScore W2280491652C2910067630 @default.
- W2280491652 hasConceptScore W2280491652C42219234 @default.
- W2280491652 hasConceptScore W2280491652C6557445 @default.
- W2280491652 hasConceptScore W2280491652C71924100 @default.
- W2280491652 hasConceptScore W2280491652C86803240 @default.
- W2280491652 hasConceptScore W2280491652C98274493 @default.
- W2280491652 hasConceptScore W2280491652C99454951 @default.
- W2280491652 hasIssue "1" @default.
- W2280491652 hasLocation W22804916521 @default.
- W2280491652 hasLocation W22804916522 @default.
- W2280491652 hasOpenAccess W2280491652 @default.
- W2280491652 hasPrimaryLocation W22804916521 @default.
- W2280491652 hasRelatedWork W1975445690 @default.
- W2280491652 hasRelatedWork W2079083816 @default.
- W2280491652 hasRelatedWork W2087923910 @default.
- W2280491652 hasRelatedWork W2164221591 @default.
- W2280491652 hasRelatedWork W2280491652 @default.
- W2280491652 hasRelatedWork W2398072304 @default.
- W2280491652 hasRelatedWork W2461568307 @default.
- W2280491652 hasRelatedWork W3104542639 @default.
- W2280491652 hasRelatedWork W78605329 @default.
- W2280491652 hasRelatedWork W2464263635 @default.
- W2280491652 hasVolume "23" @default.
- W2280491652 isParatext "false" @default.
- W2280491652 isRetracted "false" @default.
- W2280491652 magId "2280491652" @default.
- W2280491652 workType "article" @default.