FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2280495045> ?p ?o ?g. }

• W2280495045 endingPage "E233" @default.
• W2280495045 startingPage "E228" @default.
• W2280495045 abstract "The lumped constant (LC) is used to convert the clearance rate of 2-deoxy-d-glucose (2-DG cr ) to that of glucose (Glc cr ). There are currently no data to validate the widely used assumption of an LC of 1.0 for human skeletal muscle. We determined the LC for 2-deoxy-[1- 14 C]glucose (2-DG) in 18 normal male subjects (age, 29 ± 2 yr; body mass index, 24.8 ± 0.8 kg/m 2 ) after an overnight fast and during physiological (1 mU · kg −1 · min −1 insulin infusion for 180 min) and supraphysiological (5 mU · kg −1 · min −1 insulin infusion for 180 min) hyperinsulinemic conditions. Normoglycemia was maintained with the euglycemic clamp technique. The LC was measured directly with the use of a novel triple tracer-based method. [3- 3 H]glucose, 2-[1- 14 C]DG, and [ 12 C]mannitol (Man) were injected as a bolus into the brachial artery. The concentrations of [3- 3 H]glucose and 2-[1- 14 C]DG (dpm/ml plasma) and of Man (μmol/l) were determined in 50 blood samples withdrawn from the ipsilateral deep forearm vein over 15 min after the bolus injection. The LC was calculated by a formula involving blood flow calculated from Man and the Glc cr and 2-DG cr . The LC averaged 1.26 ± 0.08 (range 1.06–1.43), 1.15 ± 0.05 (0.99–1.39), and 1.18 ± 0.05 (0.97–1.37) under fasting conditions and during the 1 and 5 mU · kg −1 · min −1 insulin infusions (not significant between the different insulin concentrations, mean LC = 1.2, P < 0.01 vs. 1.0). We conclude that, in normal subjects, the LC for 2-DG in human skeletal muscle is constant over a wide range of insulin concentrations and averages 1.2." @default.
• W2280495045 created "2016-06-24" @default.
• W2280495045 creator A5026228486 @default.
• W2280495045 creator A5026993688 @default.
• W2280495045 creator A5028953583 @default.
• W2280495045 creator A5044746434 @default.
• W2280495045 creator A5046119538 @default.
• W2280495045 creator A5050209565 @default.
• W2280495045 creator A5060866444 @default.
• W2280495045 creator A5073917506 @default.
• W2280495045 date "2000-07-01" @default.
• W2280495045 modified "2023-10-16" @default.
• W2280495045 title "Direct measurement of the lumped constant for 2-deoxy-[1-¹⁴C]glucose in vivo in human skeletal muscle" @default.
• W2280495045 cites W14200900 @default.
• W2280495045 cites W1615351448 @default.
• W2280495045 cites W1783890436 @default.
• W2280495045 cites W1836632490 @default.
• W2280495045 cites W1907993061 @default.
• W2280495045 cites W1970629939 @default.
• W2280495045 cites W1986629896 @default.
• W2280495045 cites W1988068201 @default.
• W2280495045 cites W1999857843 @default.
• W2280495045 cites W2029830535 @default.
• W2280495045 cites W2036515253 @default.
• W2280495045 cites W2036641620 @default.
• W2280495045 cites W2043498565 @default.
• W2280495045 cites W2051228374 @default.
• W2280495045 cites W2063597354 @default.
• W2280495045 cites W2069960997 @default.
• W2280495045 cites W2081013287 @default.
• W2280495045 cites W2083974079 @default.
• W2280495045 cites W2084243081 @default.
• W2280495045 cites W2089671180 @default.
• W2280495045 cites W2090203522 @default.
• W2280495045 cites W2090306035 @default.
• W2280495045 cites W2094607582 @default.
• W2280495045 cites W2095631554 @default.
• W2280495045 cites W2096419248 @default.
• W2280495045 cites W2112538182 @default.
• W2280495045 cites W2115486658 @default.
• W2280495045 cites W2118976195 @default.
• W2280495045 cites W2126797816 @default.
• W2280495045 cites W2153680680 @default.
• W2280495045 cites W2156401392 @default.
• W2280495045 cites W2157271972 @default.
• W2280495045 cites W2162816616 @default.
• W2280495045 cites W2164884154 @default.
• W2280495045 cites W2172097249 @default.
• W2280495045 cites W2281243857 @default.
• W2280495045 cites W2287881467 @default.
• W2280495045 cites W2415825209 @default.
• W2280495045 cites W2421449894 @default.
• W2280495045 cites W2464541668 @default.
• W2280495045 doi "https://doi.org/10.1152/ajpendo.2000.279.1.e228" @default.
• W2280495045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10893344" @default.
• W2280495045 hasPublicationYear "2000" @default.
• W2280495045 type Work @default.
• W2280495045 sameAs 2280495045 @default.
• W2280495045 citedByCount "15" @default.
• W2280495045 countsByYear W22804950452013 @default.
• W2280495045 crossrefType "journal-article" @default.
• W2280495045 hasAuthorship W2280495045A5026228486 @default.
• W2280495045 hasAuthorship W2280495045A5026993688 @default.
• W2280495045 hasAuthorship W2280495045A5028953583 @default.
• W2280495045 hasAuthorship W2280495045A5044746434 @default.
• W2280495045 hasAuthorship W2280495045A5046119538 @default.
• W2280495045 hasAuthorship W2280495045A5050209565 @default.
• W2280495045 hasAuthorship W2280495045A5060866444 @default.
• W2280495045 hasAuthorship W2280495045A5073917506 @default.
• W2280495045 hasBestOaLocation W22804950451 @default.
• W2280495045 hasConcept C134018914 @default.
• W2280495045 hasConcept C150903083 @default.
• W2280495045 hasConcept C185592680 @default.
• W2280495045 hasConcept C186060115 @default.
• W2280495045 hasConcept C199360897 @default.
• W2280495045 hasConcept C207001950 @default.
• W2280495045 hasConcept C2777027219 @default.
• W2280495045 hasConcept C2779959927 @default.
• W2280495045 hasConcept C33923547 @default.
• W2280495045 hasConcept C41008148 @default.
• W2280495045 hasConcept C86803240 @default.
• W2280495045 hasConceptScore W2280495045C134018914 @default.
• W2280495045 hasConceptScore W2280495045C150903083 @default.
• W2280495045 hasConceptScore W2280495045C185592680 @default.
• W2280495045 hasConceptScore W2280495045C186060115 @default.
• W2280495045 hasConceptScore W2280495045C199360897 @default.
• W2280495045 hasConceptScore W2280495045C207001950 @default.
• W2280495045 hasConceptScore W2280495045C2777027219 @default.
• W2280495045 hasConceptScore W2280495045C2779959927 @default.
• W2280495045 hasConceptScore W2280495045C33923547 @default.
• W2280495045 hasConceptScore W2280495045C41008148 @default.
• W2280495045 hasConceptScore W2280495045C86803240 @default.
• W2280495045 hasIssue "1" @default.
• W2280495045 hasLocation W22804950451 @default.
• W2280495045 hasLocation W22804950452 @default.
• W2280495045 hasOpenAccess W2280495045 @default.
• W2280495045 hasPrimaryLocation W22804950451 @default.
• W2280495045 hasRelatedWork W1770232184 @default.

• next