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• W2280546424 endingPage "178" @default.
• W2280546424 startingPage "149" @default.
• W2280546424 abstract "A central sensor of the availability of growth factors, nutrients, and energy sources, the mammalian target of rapamycin complex 1 (mTORC1) is an intracellular serine/threonine kinase which plays a key role in mammalian cell growth, proliferation, survival, and metabolism. Inhibitors of the mTORC1 kinase, including rapamycin (sirolimus), RAD001 (everolimus), CCI-779 (temsirolimus), and AP23573 (deforolimus), have been shown to have broad antitumor activity pre-clinically in experimental tumor models as well as clinically in cancer patients. The central role of mTORC1 in cell growth and metabolism suggests a promising drug combination potential, with mTORC1 inhibition sensitizing tumor cells to other anticancer agents. In this chapter we review the pre-clinical data supporting the combination of targeted and cytotoxic therapeutics with mTORC1 inhibitors. We assess this in the context of molecular aspects of mTORC1 inhibition and cross talk between different signaling pathways involved in malignant transformation. The known role of mTORC1 in the development of resistance to cancer therapies, as well as the potential for bypass mechanisms which may contribute to resistance to mTORC1 inhibitors, is presented in the context of preventing resistance through rationale drug combinations. Where full manuscripts are available, reference to supporting clinical data is provided." @default.
• W2280546424 created "2016-06-24" @default.
• W2280546424 creator A5025092706 @default.
• W2280546424 creator A5082438939 @default.
• W2280546424 date "2009-01-01" @default.
• W2280546424 modified "2023-09-24" @default.
• W2280546424 title "Drug Combinations as a Therapeutic Approach for mTORC1 Inhibitors in Human Cancer" @default.
• W2280546424 cites W1480445443 @default.
• W2280546424 cites W1607134312 @default.
• W2280546424 cites W1966535797 @default.
• W2280546424 cites W1968266432 @default.
• W2280546424 cites W1971275552 @default.
• W2280546424 cites W1972655588 @default.
• W2280546424 cites W1973299943 @default.
• W2280546424 cites W1974024530 @default.
• W2280546424 cites W1974091059 @default.
• W2280546424 cites W1974969947 @default.
• W2280546424 cites W1975842578 @default.
• W2280546424 cites W1976643073 @default.
• W2280546424 cites W1977427732 @default.
• W2280546424 cites W1977786378 @default.
• W2280546424 cites W1979782687 @default.
• W2280546424 cites W1980102456 @default.
• W2280546424 cites W1980115097 @default.
• W2280546424 cites W1980299983 @default.
• W2280546424 cites W1980848382 @default.
• W2280546424 cites W1981817858 @default.
• W2280546424 cites W1985453548 @default.
• W2280546424 cites W1985934694 @default.
• W2280546424 cites W1986763334 @default.
• W2280546424 cites W1987484454 @default.
• W2280546424 cites W1987959125 @default.
• W2280546424 cites W1988184140 @default.
• W2280546424 cites W1988668248 @default.
• W2280546424 cites W1988976358 @default.
• W2280546424 cites W1990841870 @default.
• W2280546424 cites W1992101010 @default.
• W2280546424 cites W1995347299 @default.
• W2280546424 cites W1999720438 @default.
• W2280546424 cites W1999932935 @default.
• W2280546424 cites W200072792 @default.
• W2280546424 cites W2001366190 @default.
• W2280546424 cites W2006384445 @default.
• W2280546424 cites W2007110714 @default.
• W2280546424 cites W2008585163 @default.
• W2280546424 cites W2011424260 @default.
• W2280546424 cites W2013988606 @default.
• W2280546424 cites W2014096417 @default.
• W2280546424 cites W2015062933 @default.
• W2280546424 cites W2015562061 @default.
• W2280546424 cites W2017605860 @default.
• W2280546424 cites W2018133940 @default.
• W2280546424 cites W2020372547 @default.
• W2280546424 cites W2020844485 @default.
• W2280546424 cites W2022461483 @default.
• W2280546424 cites W2024086004 @default.
• W2280546424 cites W2026125986 @default.
• W2280546424 cites W2026199302 @default.
• W2280546424 cites W2026216334 @default.
• W2280546424 cites W2026351725 @default.
• W2280546424 cites W2026569756 @default.
• W2280546424 cites W2028704745 @default.
• W2280546424 cites W2029098356 @default.
• W2280546424 cites W2029882446 @default.
• W2280546424 cites W2030440427 @default.
• W2280546424 cites W2032751670 @default.
• W2280546424 cites W2032870664 @default.
• W2280546424 cites W2035521247 @default.
• W2280546424 cites W2035521896 @default.
• W2280546424 cites W2036834298 @default.
• W2280546424 cites W2037177985 @default.
• W2280546424 cites W2037403469 @default.
• W2280546424 cites W2038598054 @default.
• W2280546424 cites W2038620630 @default.
• W2280546424 cites W2038683465 @default.
• W2280546424 cites W2038884210 @default.
• W2280546424 cites W2039205618 @default.
• W2280546424 cites W2040189554 @default.
• W2280546424 cites W2041928869 @default.
• W2280546424 cites W2044467623 @default.
• W2280546424 cites W2049579456 @default.
• W2280546424 cites W2049970665 @default.
• W2280546424 cites W2052093947 @default.
• W2280546424 cites W2053217945 @default.
• W2280546424 cites W2055729918 @default.
• W2280546424 cites W2055827129 @default.
• W2280546424 cites W2058829665 @default.
• W2280546424 cites W2059411043 @default.
• W2280546424 cites W2059890247 @default.
• W2280546424 cites W2062541888 @default.
• W2280546424 cites W2067114310 @default.
• W2280546424 cites W2071394735 @default.
• W2280546424 cites W2071854453 @default.
• W2280546424 cites W2074389750 @default.
• W2280546424 cites W2074433596 @default.
• W2280546424 cites W2076203883 @default.
• W2280546424 cites W2077735413 @default.
• W2280546424 cites W2079384315 @default.

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