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• W2280578760 abstract "5082 Background: Carboplatin (C) is a standard treatment for gynecologic cancers, but its use in recurrence is associated with an increased risk of hypersensitivity reactions (HSR) in those previously treated with C. However there is no way to predict those at risk for a C-HSR. We sought to evaluate whether the time between C was predictive of incidence and severity of HSRs. Methods: Patients treated with C between 1/1997 and 12/2005 were identified through our chemotherapy database. Records were reviewed for: dates and number of C regimens and cycles, age, drug allergies, cancer type, and date and symptoms of HSR. Severity was defined as mild if symptoms were rash, pruritis or severe for hypo/hypertension, vomiting, dyspnea, wheezing, chest pain, edema, rigors or generalized hives. Fisher’s exact test or Chi Square was used to compare categorized variables. Results: 126 patients were identified who had multiple C regimens. The median age was 60 (range, 40–90) and 89% were treated for ovarian cancer. 63 (50%) experienced C HSRs of which 36 (29%) were severe. The mean time between C regimens was 21 months for those with no HSRs and 24 months for those with HSRs (p = 0.1). The time between C regimens significantly predicted the incidence of HSRs (see table ). Of those receiving a 3 rd regimen of C, 8/8 had a HSR and these were severe in seven (88%). Neither age nor presence of other drug allergies was associated with a risk of C HSR. Of interest, 60 patients received >8 (range 9–19) cycles with the first C regimen, and none of the patients reacted after cycle 8. Conclusions: A duration of greater than 12 months between C regimens is associated with an increased risk of both any- and severe- HSR. Our data also suggests that upfront treatment with C beyond eight cycles is not associated with an increased risk of HSR. Strategies for decreasing the risk of C HSR may be best focused on women receiving a repeat regimen after a platinum-free duration over 12 months or those receiving a 3 rd regimen of C. [Table: see text] No significant financial relationships to disclose." @default.
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• W2280578760 date "2006-06-20" @default.
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• W2280578760 title "Does the platinum-free interval predict the incidence or severity of hypersensitivity reactions to carboplatin? The experience from Women & Infants’ Hospital" @default.
• W2280578760 doi "https://doi.org/10.1200/jco.2006.24.18_suppl.5082" @default.
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