FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2280593936> ?p ?o ?g. }

• W2280593936 endingPage "920" @default.
• W2280593936 startingPage "912" @default.
• W2280593936 abstract "Adipose tissue (AT) autophagy gene expression is elevated in human obesity, correlating with increased metabolic risk, but mechanistic links between the two remain unclear. Thus, the objective of this study was to assess whether elevated autophagy may cause AT endocrine dysfunction, emphasizing the putative role of adiponectin in fat–liver endocrine communication. We utilized a large (N=186) human AT biobank to assess clinical associations between human visceral AT autophagy genes, adiponectin and leptin, by multivariate models. A broader view of adipocytokines association with elevated autophagy was assessed using adipocytokine array. Finally, to establish causality, ex vivo studies utilizing a murine AT–hepatocyte cell line co-culture system was used. Circulating high-molecular-weight adiponectin and leptin levels were associated with human omental-AT expression of ATG5 mRNA, associations that remained significant (β=−0.197, P=0.011; β=0.267, P<0.001, respectively) in a multivariate model adjusted for age, sex, body mass index and interleukin-6 (IL-6). A similar association was observed with omental-AT LC3A mRNA levels. Bafilomycin-A1 (Baf A) pretreatment of AT explants from high-fat-fed (HFF) mice had no effect on the secretion of some AT-derived endocrine factors, but partially or fully reversed obesity-related changes in secretion of a subset of adipocytokines by >30%, including the obesity-associated upregulation of IL-6, vascular endothelial growth factor, tumor necrosis factor alpha (TNFα) and certain insulin-like growth factor-binding proteins, and the HFF-induced downregulated secretion of IL-10 and adiponectin. Similarly, decreased adiponectin and increased leptin secretion from cultured adipocytes stimulated with TNFα+IL-1β was partially reversed by small interfering RNA-mediated knockdown of ATG7. AT explants from HFF mice co-cultured with Hepa1c hepatoma cells impaired insulin-induced Akt and GSK3 phosphorylation. This effect was significantly reversed by pretreating explants with Baf A, but not if adiponectin was immunodepleted from the conditioned media. Reduced secretion of adiponectin may link obesity-associated elevated AT autophagy/lysosomal activity with adipose endocrine dysfunction." @default.
• W2280593936 created "2016-06-24" @default.
• W2280593936 creator A5003583279 @default.
• W2280593936 creator A5008490135 @default.
• W2280593936 creator A5014581353 @default.
• W2280593936 creator A5014740581 @default.
• W2280593936 creator A5015385223 @default.
• W2280593936 creator A5034227003 @default.
• W2280593936 creator A5053333088 @default.
• W2280593936 creator A5054102397 @default.
• W2280593936 creator A5073471236 @default.
• W2280593936 creator A5082416424 @default.
• W2280593936 creator A5088456518 @default.
• W2280593936 date "2016-01-20" @default.
• W2280593936 modified "2023-10-14" @default.
• W2280593936 title "Decreased adiponectin links elevated adipose tissue autophagy with adipocyte endocrine dysfunction in obesity" @default.
• W2280593936 cites W1525943215 @default.
• W2280593936 cites W1976844022 @default.
• W2280593936 cites W1978145149 @default.
• W2280593936 cites W1979514353 @default.
• W2280593936 cites W1979899635 @default.
• W2280593936 cites W1986342371 @default.
• W2280593936 cites W1987769185 @default.
• W2280593936 cites W1991309264 @default.
• W2280593936 cites W2004196710 @default.
• W2280593936 cites W2007743440 @default.
• W2280593936 cites W2018825408 @default.
• W2280593936 cites W2023857290 @default.
• W2280593936 cites W2040280675 @default.
• W2280593936 cites W2051372717 @default.
• W2280593936 cites W2062754223 @default.
• W2280593936 cites W2076667569 @default.
• W2280593936 cites W2093712462 @default.
• W2280593936 cites W2095008495 @default.
• W2280593936 cites W2109058559 @default.
• W2280593936 cites W2111990033 @default.
• W2280593936 cites W2112121424 @default.
• W2280593936 cites W2135552411 @default.
• W2280593936 cites W2147062583 @default.
• W2280593936 cites W2154846778 @default.
• W2280593936 cites W2157495503 @default.
• W2280593936 cites W2164778558 @default.
• W2280593936 cites W2167117819 @default.
• W2280593936 doi "https://doi.org/10.1038/ijo.2016.5" @default.
• W2280593936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26786352" @default.
• W2280593936 hasPublicationYear "2016" @default.
• W2280593936 type Work @default.
• W2280593936 sameAs 2280593936 @default.
• W2280593936 citedByCount "28" @default.
• W2280593936 countsByYear W22805939362017 @default.
• W2280593936 countsByYear W22805939362018 @default.
• W2280593936 countsByYear W22805939362019 @default.
• W2280593936 countsByYear W22805939362020 @default.
• W2280593936 countsByYear W22805939362021 @default.
• W2280593936 countsByYear W22805939362022 @default.
• W2280593936 countsByYear W22805939362023 @default.
• W2280593936 crossrefType "journal-article" @default.
• W2280593936 hasAuthorship W2280593936A5003583279 @default.
• W2280593936 hasAuthorship W2280593936A5008490135 @default.
• W2280593936 hasAuthorship W2280593936A5014581353 @default.
• W2280593936 hasAuthorship W2280593936A5014740581 @default.
• W2280593936 hasAuthorship W2280593936A5015385223 @default.
• W2280593936 hasAuthorship W2280593936A5034227003 @default.
• W2280593936 hasAuthorship W2280593936A5053333088 @default.
• W2280593936 hasAuthorship W2280593936A5054102397 @default.
• W2280593936 hasAuthorship W2280593936A5073471236 @default.
• W2280593936 hasAuthorship W2280593936A5082416424 @default.
• W2280593936 hasAuthorship W2280593936A5088456518 @default.
• W2280593936 hasBestOaLocation W22805939361 @default.
• W2280593936 hasConcept C126322002 @default.
• W2280593936 hasConcept C134018914 @default.
• W2280593936 hasConcept C171089720 @default.
• W2280593936 hasConcept C190283241 @default.
• W2280593936 hasConcept C194832188 @default.
• W2280593936 hasConcept C203522944 @default.
• W2280593936 hasConcept C2776175234 @default.
• W2280593936 hasConcept C2776782570 @default.
• W2280593936 hasConcept C2777391703 @default.
• W2280593936 hasConcept C2779306644 @default.
• W2280593936 hasConcept C2780613262 @default.
• W2280593936 hasConcept C511355011 @default.
• W2280593936 hasConcept C55493867 @default.
• W2280593936 hasConcept C71924100 @default.
• W2280593936 hasConcept C86803240 @default.
• W2280593936 hasConceptScore W2280593936C126322002 @default.
• W2280593936 hasConceptScore W2280593936C134018914 @default.
• W2280593936 hasConceptScore W2280593936C171089720 @default.
• W2280593936 hasConceptScore W2280593936C190283241 @default.
• W2280593936 hasConceptScore W2280593936C194832188 @default.
• W2280593936 hasConceptScore W2280593936C203522944 @default.
• W2280593936 hasConceptScore W2280593936C2776175234 @default.
• W2280593936 hasConceptScore W2280593936C2776782570 @default.
• W2280593936 hasConceptScore W2280593936C2777391703 @default.
• W2280593936 hasConceptScore W2280593936C2779306644 @default.
• W2280593936 hasConceptScore W2280593936C2780613262 @default.
• W2280593936 hasConceptScore W2280593936C511355011 @default.
• W2280593936 hasConceptScore W2280593936C55493867 @default.
• W2280593936 hasConceptScore W2280593936C71924100 @default.

• next