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- W2280665713 abstract "Streptococcus pyogenes infections have been associated with two autoimmune diseases of the CNS: Sydenham's chorea (SC) and pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections (PANDAS). Despite the high frequency of pharyngeal streptococcus infections among children, only a small fraction develops SC or PANDAS. This suggests that several factors in combination are necessary to trigger autoimmune complications: specific S. pyogenes strains that induce a strong immune response toward the host nervous system; genetic susceptibility that predispose children toward an autoimmune response involving movement or tic symptoms; and multiple infections of the throat or tonsils that lead to a robust T h 17 cellular and humoral immune response when untreated. In this review, we summarize the evidence for each factor and propose that all must be met for the requisite neurovascular pathology and behavioral deficits found in SC/PANDAS." @default.
- W2280665713 created "2016-06-24" @default.
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- W2280665713 creator A5053234667 @default.
- W2280665713 creator A5054011101 @default.
- W2280665713 creator A5085315691 @default.
- W2280665713 date "2016-02-01" @default.
- W2280665713 modified "2023-10-17" @default.
- W2280665713 title "CNS autoimmune disease after <i>Streptococcus pyogenes</i> infections: animal models, cellular mechanisms and genetic factors" @default.
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- W2280665713 doi "https://doi.org/10.2217/fnl.16.4" @default.
- W2280665713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4839655" @default.
- W2280665713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27110222" @default.
- W2280665713 hasPublicationYear "2016" @default.
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