Matches in SemOpenAlex for { <https://semopenalex.org/work/W2280698737> ?p ?o ?g. }
- W2280698737 endingPage "11" @default.
- W2280698737 startingPage "1" @default.
- W2280698737 abstract "Genetic variations in oncogenes can often promote uncontrolled cell proliferation by altering the structure of the encoded protein, thereby altering its function. The PI3KCA oncogene that encodes for p110α, the catalytic subunit of phosphatidylinositol 3-kinase (PI3K), is one the most frequently mutated oncogenes in humans. PI3K plays a pivotal role in cell division. PI3K consists of two subunits: the catalytic (p110α) and regulatory (p85α). The regulatory subunit usually controls the catalytic subunit and switches off the enzyme when not required. It is believed that mutations in PI3KCA gene can alter the control of p85α over p110α and can sustain p110α in a prolonged active state. This in turn results in uncontrolled cell division. In this study, we investigate the pathogenic role of two point mutations: E542K and E545K on p110α subunit and how they alter its binding with the regulatory subunit. Molecular interaction and molecular dynamic simulation analysis are performed to study the dynamic behaviour of native and mutant structures at atomic level. Mutant p110α showed less interaction with its regulatory partner p85α than the native did, due to its expanded and rigid structure. Our analysis clearly points out that the structural and functional consequences of the mutations could promote tumour proliferation." @default.
- W2280698737 created "2016-06-24" @default.
- W2280698737 creator A5057976884 @default.
- W2280698737 creator A5060522544 @default.
- W2280698737 creator A5079148112 @default.
- W2280698737 creator A5087385312 @default.
- W2280698737 date "2016-02-23" @default.
- W2280698737 modified "2023-09-25" @default.
- W2280698737 title "Biophysical aspect of phosphatidylinositol 3-kinase and role of oncogenic mutants (E542K & E545K)" @default.
- W2280698737 cites W1966078827 @default.
- W2280698737 cites W1978106273 @default.
- W2280698737 cites W1985792114 @default.
- W2280698737 cites W1990194768 @default.
- W2280698737 cites W1995017064 @default.
- W2280698737 cites W1998157605 @default.
- W2280698737 cites W2009886463 @default.
- W2280698737 cites W2014031706 @default.
- W2280698737 cites W2021876859 @default.
- W2280698737 cites W2025299147 @default.
- W2280698737 cites W2027361781 @default.
- W2280698737 cites W2029667189 @default.
- W2280698737 cites W2035266068 @default.
- W2280698737 cites W2035687084 @default.
- W2280698737 cites W2051628563 @default.
- W2280698737 cites W2052868118 @default.
- W2280698737 cites W2053538195 @default.
- W2280698737 cites W2054544606 @default.
- W2280698737 cites W2054607545 @default.
- W2280698737 cites W2054958296 @default.
- W2280698737 cites W2055614052 @default.
- W2280698737 cites W2057370954 @default.
- W2280698737 cites W2067040565 @default.
- W2280698737 cites W2070841378 @default.
- W2280698737 cites W2078159738 @default.
- W2280698737 cites W2081912151 @default.
- W2280698737 cites W2087431066 @default.
- W2280698737 cites W2091734240 @default.
- W2280698737 cites W2094686651 @default.
- W2280698737 cites W2099857980 @default.
- W2280698737 cites W2105844209 @default.
- W2280698737 cites W2110120447 @default.
- W2280698737 cites W2120943945 @default.
- W2280698737 cites W2129172946 @default.
- W2280698737 cites W2134629247 @default.
- W2280698737 cites W2137167381 @default.
- W2280698737 cites W2144081223 @default.
- W2280698737 cites W2153983456 @default.
- W2280698737 cites W2154608911 @default.
- W2280698737 cites W2162362489 @default.
- W2280698737 cites W2164139183 @default.
- W2280698737 cites W2915573764 @default.
- W2280698737 cites W4207058970 @default.
- W2280698737 cites W4243559800 @default.
- W2280698737 cites W4255916494 @default.
- W2280698737 cites W4256367673 @default.
- W2280698737 doi "https://doi.org/10.1080/07391102.2015.1127774" @default.
- W2280698737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26646651" @default.
- W2280698737 hasPublicationYear "2016" @default.
- W2280698737 type Work @default.
- W2280698737 sameAs 2280698737 @default.
- W2280698737 citedByCount "17" @default.
- W2280698737 countsByYear W22806987372016 @default.
- W2280698737 countsByYear W22806987372017 @default.
- W2280698737 countsByYear W22806987372018 @default.
- W2280698737 countsByYear W22806987372019 @default.
- W2280698737 countsByYear W22806987372020 @default.
- W2280698737 countsByYear W22806987372021 @default.
- W2280698737 crossrefType "journal-article" @default.
- W2280698737 hasAuthorship W2280698737A5057976884 @default.
- W2280698737 hasAuthorship W2280698737A5060522544 @default.
- W2280698737 hasAuthorship W2280698737A5079148112 @default.
- W2280698737 hasAuthorship W2280698737A5087385312 @default.
- W2280698737 hasConcept C104292427 @default.
- W2280698737 hasConcept C104317684 @default.
- W2280698737 hasConcept C143065580 @default.
- W2280698737 hasConcept C1491633281 @default.
- W2280698737 hasConcept C176944494 @default.
- W2280698737 hasConcept C184235292 @default.
- W2280698737 hasConcept C185592680 @default.
- W2280698737 hasConcept C2780610907 @default.
- W2280698737 hasConcept C2781018059 @default.
- W2280698737 hasConcept C2781465904 @default.
- W2280698737 hasConcept C29537977 @default.
- W2280698737 hasConcept C501734568 @default.
- W2280698737 hasConcept C54355233 @default.
- W2280698737 hasConcept C62112901 @default.
- W2280698737 hasConcept C62478195 @default.
- W2280698737 hasConcept C85813293 @default.
- W2280698737 hasConcept C86554907 @default.
- W2280698737 hasConcept C86803240 @default.
- W2280698737 hasConcept C95444343 @default.
- W2280698737 hasConceptScore W2280698737C104292427 @default.
- W2280698737 hasConceptScore W2280698737C104317684 @default.
- W2280698737 hasConceptScore W2280698737C143065580 @default.
- W2280698737 hasConceptScore W2280698737C1491633281 @default.
- W2280698737 hasConceptScore W2280698737C176944494 @default.
- W2280698737 hasConceptScore W2280698737C184235292 @default.
- W2280698737 hasConceptScore W2280698737C185592680 @default.