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• W2280942156 abstract "Magnetic resonance imaging (MRI) intensities are acquired in arbitrary units, making scans non-comparable across sites and between subjects. Intensity normalization is a first step for the improvement of comparability of the images across subjects. However, we show that unwanted inter-scan variability associated with imaging site, scanner effect, and other technical artifacts is still present after standard intensity normalization in large multi-site neuroimaging studies. We propose RAVEL (Removal of Artificial Voxel Effect by Linear regression), a tool to remove residual technical variability after intensity normalization. As proposed by SVA and RUV [Leek and Storey, 2007, 2008, Gagnon-Bartsch and Speed, 2012], two batch effect correction tools largely used in genomics, we decompose the voxel intensities of images registered to a template into a biological component and an unwanted variation component. The unwanted variation component is estimated from a control region obtained from the cerebrospinal fluid (CSF), where intensities are known to be unassociated with disease status and other clinical covariates. We perform a singular value decomposition (SVD) of the control voxels to estimate factors of unwanted variation. We then estimate the unwanted factors using linear regression for every voxel of the brain and take the residuals as the RAVEL-corrected intensities. We assess the performance of RAVEL using T1-weighted (T1-w) images from more than 900 subjects with Alzheimer's disease (AD) and mild cognitive impairment (MCI), as well as healthy controls from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. We compare RAVEL to two intensity-normalization-only methods: histogram matching and White Stripe. We show that RAVEL performs best at improving the replicability of the brain regions that are empirically found to be most associated with AD, and that these regions are significantly more present in structures impacted by AD (hippocampus, amygdala, parahippocampal gyrus, enthorinal area, and fornix stria terminals). In addition, we show that the RAVEL-corrected intensities have the best performance in distinguishing between MCI subjects and healthy subjects using the mean hippocampal intensity (AUC=67%), a marked improvement compared to results from intensity normalization alone (AUC=63% and 59% for histogram matching and White Stripe, respectively). RAVEL is promising for many other imaging modalities." @default.
• W2280942156 created "2016-06-24" @default.
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• W2280942156 creator A5089030792 @default.
• W2280942156 date "2016-05-01" @default.
• W2280942156 modified "2023-10-07" @default.
• W2280942156 title "Removing inter-subject technical variability in magnetic resonance imaging studies" @default.
• W2280942156 cites W1622128722 @default.
• W2280942156 cites W1905027248 @default.
• W2280942156 cites W1963995030 @default.
• W2280942156 cites W1966100017 @default.
• W2280942156 cites W1967028508 @default.
• W2280942156 cites W1970300450 @default.
• W2280942156 cites W1970928383 @default.
• W2280942156 cites W1974985199 @default.
• W2280942156 cites W1979376506 @default.
• W2280942156 cites W1982429911 @default.
• W2280942156 cites W1987011701 @default.
• W2280942156 cites W1991463855 @default.
• W2280942156 cites W1996595747 @default.
• W2280942156 cites W1998604842 @default.
• W2280942156 cites W2000070752 @default.
• W2280942156 cites W2001648635 @default.
• W2280942156 cites W2006096283 @default.
• W2280942156 cites W2007483873 @default.
• W2280942156 cites W2013016035 @default.
• W2280942156 cites W2015629132 @default.
• W2280942156 cites W2016703884 @default.
• W2280942156 cites W2018275328 @default.
• W2280942156 cites W2021720039 @default.
• W2280942156 cites W2024103316 @default.
• W2280942156 cites W2025915778 @default.
• W2280942156 cites W2035351162 @default.
• W2280942156 cites W2041868509 @default.
• W2280942156 cites W2044367669 @default.
• W2280942156 cites W2045867209 @default.
• W2280942156 cites W2051588049 @default.
• W2280942156 cites W2054346790 @default.
• W2280942156 cites W2055052967 @default.
• W2280942156 cites W2060295418 @default.
• W2280942156 cites W2063517158 @default.
• W2280942156 cites W2067145795 @default.
• W2280942156 cites W2069317808 @default.
• W2280942156 cites W2071415177 @default.
• W2280942156 cites W2071881327 @default.
• W2280942156 cites W2078524519 @default.
• W2280942156 cites W2086051541 @default.
• W2280942156 cites W2086900658 @default.
• W2280942156 cites W2086978209 @default.
• W2280942156 cites W2089244634 @default.
• W2280942156 cites W2092497652 @default.
• W2280942156 cites W2094102206 @default.
• W2280942156 cites W2096192437 @default.
• W2280942156 cites W2096609500 @default.
• W2280942156 cites W2101886699 @default.
• W2280942156 cites W2102508963 @default.
• W2280942156 cites W2116650193 @default.
• W2280942156 cites W2117340355 @default.
• W2280942156 cites W2117602475 @default.
• W2280942156 cites W2119848633 @default.
• W2280942156 cites W2122982115 @default.
• W2280942156 cites W2123927491 @default.
• W2280942156 cites W2128197886 @default.
• W2280942156 cites W2129915465 @default.
• W2280942156 cites W2130331029 @default.
• W2280942156 cites W2136573752 @default.
• W2280942156 cites W2137499573 @default.
• W2280942156 cites W2141009231 @default.
• W2280942156 cites W2143731392 @default.
• W2280942156 cites W2147324044 @default.
• W2280942156 cites W2147575460 @default.
• W2280942156 cites W2149128281 @default.
• W2280942156 cites W2151920318 @default.
• W2280942156 cites W2154158661 @default.
• W2280942156 cites W2159037096 @default.
• W2280942156 cites W2159320983 @default.
• W2280942156 cites W2159838014 @default.
• W2280942156 cites W2162069081 @default.
• W2280942156 cites W2162613378 @default.
• W2280942156 cites W2163980871 @default.
• W2280942156 cites W2166219471 @default.
• W2280942156 cites W2166549811 @default.
• W2280942156 cites W2410237123 @default.
• W2280942156 cites W2500528961 @default.
• W2280942156 cites W4249221250 @default.
• W2280942156 doi "https://doi.org/10.1016/j.neuroimage.2016.02.036" @default.
• W2280942156 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5540379" @default.
• W2280942156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26923370" @default.
• W2280942156 hasPublicationYear "2016" @default.
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