Matches in SemOpenAlex for { <https://semopenalex.org/work/W2281005349> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2281005349 endingPage "24" @default.
- W2281005349 startingPage "13" @default.
- W2281005349 abstract "Synthetic combinatorial libraries (SCLs) are collections of very large numbers of synthetic compounds, in which all possible combinations of the burlding blocks used are represented. The development and verification of the utility of combinatorial libraries represent a dramatic advance in the drug discovery process by greatly reducing the time needed to identify new drug leads. Positional scanning (PS) SCLs (,) represent a modified format of the origmal synthetic combinatorial libraries described by this laboratory (). In contrast to the original libraries, which required several iterative syntheses to identify individual active compounds, this library format provides mformation on the substituent responsible for activity at each varied position withm a structure. Therefore, only a single subsequent synthesis is required. The screening of PS-SCLs, in most instances, permits the identification of the most active substituents at each position of a compound in a single assay. Thus PS-SCLs serve to reduce further the time required to identify new drug leads. PS-SCLs are composed of individual positional SCLs, in which a single position is defined with one substituent while the remaining positions are composed of mixtures of substituents. The defined position is “walked” through the entire sequence of the PS-SCL. Therefore, the number of positional SCLs is equal to the number of residues in each compound of the PS-SCL. It should also be noted that each posrtional SCL, although addressing a single position of the sequence, represents the same collection of individual compounds For example, a hexapeptide, or a compound with six positions, can be represented as: O1XXXXX, XO2,XXXX, XXO3XXX, XXO4,XX, XXXXO5X, or XXXXXO6." @default.
- W2281005349 created "2016-06-24" @default.
- W2281005349 creator A5034015029 @default.
- W2281005349 creator A5047419813 @default.
- W2281005349 date "2003-11-14" @default.
- W2281005349 modified "2023-09-26" @default.
- W2281005349 title "Synthesis and Screening of Positional Scanning Combinatorial Libraries" @default.
- W2281005349 doi "https://doi.org/10.1385/0-89603-392-9:13" @default.
- W2281005349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9523255" @default.
- W2281005349 hasPublicationYear "2003" @default.
- W2281005349 type Work @default.
- W2281005349 sameAs 2281005349 @default.
- W2281005349 citedByCount "9" @default.
- W2281005349 countsByYear W22810053492015 @default.
- W2281005349 countsByYear W22810053492017 @default.
- W2281005349 countsByYear W22810053492018 @default.
- W2281005349 countsByYear W22810053492019 @default.
- W2281005349 crossrefType "book-chapter" @default.
- W2281005349 hasAuthorship W2281005349A5034015029 @default.
- W2281005349 hasAuthorship W2281005349A5047419813 @default.
- W2281005349 hasConcept C10138342 @default.
- W2281005349 hasConcept C162324750 @default.
- W2281005349 hasConcept C185592680 @default.
- W2281005349 hasConcept C198082294 @default.
- W2281005349 hasConcept C21951064 @default.
- W2281005349 hasConcept C2778112365 @default.
- W2281005349 hasConcept C2778689049 @default.
- W2281005349 hasConcept C2994224535 @default.
- W2281005349 hasConcept C55493867 @default.
- W2281005349 hasConcept C60644358 @default.
- W2281005349 hasConcept C70721500 @default.
- W2281005349 hasConcept C71240020 @default.
- W2281005349 hasConcept C74187038 @default.
- W2281005349 hasConcept C86803240 @default.
- W2281005349 hasConceptScore W2281005349C10138342 @default.
- W2281005349 hasConceptScore W2281005349C162324750 @default.
- W2281005349 hasConceptScore W2281005349C185592680 @default.
- W2281005349 hasConceptScore W2281005349C198082294 @default.
- W2281005349 hasConceptScore W2281005349C21951064 @default.
- W2281005349 hasConceptScore W2281005349C2778112365 @default.
- W2281005349 hasConceptScore W2281005349C2778689049 @default.
- W2281005349 hasConceptScore W2281005349C2994224535 @default.
- W2281005349 hasConceptScore W2281005349C55493867 @default.
- W2281005349 hasConceptScore W2281005349C60644358 @default.
- W2281005349 hasConceptScore W2281005349C70721500 @default.
- W2281005349 hasConceptScore W2281005349C71240020 @default.
- W2281005349 hasConceptScore W2281005349C74187038 @default.
- W2281005349 hasConceptScore W2281005349C86803240 @default.
- W2281005349 hasLocation W22810053491 @default.
- W2281005349 hasLocation W22810053492 @default.
- W2281005349 hasOpenAccess W2281005349 @default.
- W2281005349 hasPrimaryLocation W22810053491 @default.
- W2281005349 hasRelatedWork W1984596640 @default.
- W2281005349 hasRelatedWork W1986170186 @default.
- W2281005349 hasRelatedWork W2041719513 @default.
- W2281005349 hasRelatedWork W2054394969 @default.
- W2281005349 hasRelatedWork W2108918515 @default.
- W2281005349 hasRelatedWork W2125225950 @default.
- W2281005349 hasRelatedWork W2159856147 @default.
- W2281005349 hasRelatedWork W2951791903 @default.
- W2281005349 hasRelatedWork W3021294563 @default.
- W2281005349 hasRelatedWork W849564660 @default.
- W2281005349 isParatext "false" @default.
- W2281005349 isRetracted "false" @default.
- W2281005349 magId "2281005349" @default.
- W2281005349 workType "book-chapter" @default.