FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2281010> ?p ?o ?g. }

• W2281010 abstract "Pharmaceutical companies today face a growing demand for more complex drug designs. In the past few decades, a number of probabilistic models have been developed, for the purpose of giving a better insight into the microscopic features of these complex designs. Of particular interest are those models that simulate controlled release systems to provide targeted dose delivery. Controlled release is achieved by using polymers with different dissolution characteristics. We present here a model of a drug delivery system based on Monte Carlo methods, as a framework for Cellular Automata mobility, and show a solution for model enhancement through parallelisation. The objective is the high performance simulation of targeted drug release in the gastro-intestinal tract, from a capsule composed of ethylcellulose coated microspheres. The overall aim is to understand the importance of various molecular effects with respect to system evolution over time. Important underlying mechanisms of the process, such as erosion and diffusion, are described. Keywords-Drug dissolution, Probabilistic methods, Discrete simulation, Computational modelling, OpenMP parallelisation important problems to be solved. Here, we present an OpenMP based parallelisation model for simulation of 3D drug systems. The model is based on a combined Monte Carlo (MC) and Cellular Automata (CA) approach and simulates controlled release from coated microspheres. The main novelties in this work include the analysis of the effect of the coating structure on the drug release and the effort to mimic non-homogeneous dispersion of the drug, thus improving realism of the model. The research is performed in an ongoing collaboration with the industrial partner and aims to address the questions surrounding the release of the drug (cyclosporine) in targeting the gastro-intestinal (GI) tract. As one of a number of suitable coating materials, we model the use of ethylcellulose (EC), a generally non- invasive polymer with good film-forming capabilities, (hence ideal for use in matrix agents), for prolonged release, (2). Due to the thin layer of ethylcellulose used, a very fine grained model is required, prompting the need for the parallelisation. The reasons for choosing the particular parallelisation framework are outlined, together with its advantages and limitations compared to other industry standard parallelisation approaches, when applied to simulations of complex pharmaceutical systems." @default.
• W2281010 created "2016-06-24" @default.
• W2281010 creator A5038645621 @default.
• W2281010 creator A5060543167 @default.
• W2281010 creator A5022379752 @default.
• W2281010 date "2011-02-26" @default.
• W2281010 modified "2023-09-23" @default.
• W2281010 title "Modelling Drug Coatings: A parallel Cellular Automata Model of Ethylcellulose- coated Microspheres" @default.
• W2281010 cites W1490542677 @default.
• W2281010 cites W1985652626 @default.
• W2281010 cites W1990840120 @default.
• W2281010 cites W1999501080 @default.
• W2281010 cites W2044643145 @default.
• W2281010 cites W2056304970 @default.
• W2281010 cites W2056662119 @default.
• W2281010 cites W2063543655 @default.
• W2281010 cites W2068204079 @default.
• W2281010 cites W2072624182 @default.
• W2281010 cites W2073083368 @default.
• W2281010 cites W2095595785 @default.
• W2281010 cites W2096222210 @default.
• W2281010 cites W2108801243 @default.
• W2281010 cites W2156827444 @default.
• W2281010 cites W2161471969 @default.
• W2281010 cites W2168034608 @default.
• W2281010 cites W2580706326 @default.
• W2281010 cites W2596620906 @default.
• W2281010 cites W2024612426 @default.
• W2281010 hasPublicationYear "2011" @default.
• W2281010 type Work @default.
• W2281010 sameAs 2281010 @default.
• W2281010 citedByCount "2" @default.
• W2281010 countsByYear W22810102012 @default.
• W2281010 countsByYear W22810102016 @default.
• W2281010 crossrefType "book-chapter" @default.
• W2281010 hasAuthorship W2281010A5022379752 @default.
• W2281010 hasAuthorship W2281010A5038645621 @default.
• W2281010 hasAuthorship W2281010A5060543167 @default.
• W2281010 hasConcept C105795698 @default.
• W2281010 hasConcept C120314980 @default.
• W2281010 hasConcept C127413603 @default.
• W2281010 hasConcept C154945302 @default.
• W2281010 hasConcept C171250308 @default.
• W2281010 hasConcept C189942447 @default.
• W2281010 hasConcept C192562407 @default.
• W2281010 hasConcept C19499675 @default.
• W2281010 hasConcept C2779820397 @default.
• W2281010 hasConcept C2781448156 @default.
• W2281010 hasConcept C33923547 @default.
• W2281010 hasConcept C35527583 @default.
• W2281010 hasConcept C41008148 @default.
• W2281010 hasConcept C42360764 @default.
• W2281010 hasConcept C49937458 @default.
• W2281010 hasConceptScore W2281010C105795698 @default.
• W2281010 hasConceptScore W2281010C120314980 @default.
• W2281010 hasConceptScore W2281010C127413603 @default.
• W2281010 hasConceptScore W2281010C154945302 @default.
• W2281010 hasConceptScore W2281010C171250308 @default.
• W2281010 hasConceptScore W2281010C189942447 @default.
• W2281010 hasConceptScore W2281010C192562407 @default.
• W2281010 hasConceptScore W2281010C19499675 @default.
• W2281010 hasConceptScore W2281010C2779820397 @default.
• W2281010 hasConceptScore W2281010C2781448156 @default.
• W2281010 hasConceptScore W2281010C33923547 @default.
• W2281010 hasConceptScore W2281010C35527583 @default.
• W2281010 hasConceptScore W2281010C41008148 @default.
• W2281010 hasConceptScore W2281010C42360764 @default.
• W2281010 hasConceptScore W2281010C49937458 @default.
• W2281010 hasLocation W22810101 @default.
• W2281010 hasOpenAccess W2281010 @default.
• W2281010 hasPrimaryLocation W22810101 @default.
• W2281010 hasRelatedWork W2183108876 @default.
• W2281010 hasRelatedWork W2431433488 @default.
• W2281010 hasRelatedWork W2581864604 @default.
• W2281010 hasRelatedWork W2803466996 @default.
• W2281010 hasRelatedWork W3185677840 @default.
• W2281010 isParatext "false" @default.
• W2281010 isRetracted "false" @default.
• W2281010 magId "2281010" @default.
• W2281010 workType "book-chapter" @default.