FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2281018049> ?p ?o ?g. }

• W2281018049 endingPage "E1014" @default.
• W2281018049 startingPage "E1008" @default.
• W2281018049 abstract "Islet amyloid polypeptide (IAPP) is a novel amyloid-forming beta-cell hormone with putative roles in glucose metabolism and non-insulin-dependent diabetes mellitus (NIDDM) pathogenesis. To study how IAPP and insulin expression are regulated by glucose, rats were fasted for 48h followed by administration of glucose at repeated 4-h intervals; IAPP and insulin mRNA levels were determined by quantitative in situ hybridization. Fasting markedly reduced IAPP and insulin mRNA levels. Two (6 h) and four (14 h) glucose injections dose dependently increased both mRNA levels; the effects were matched by similar changes in plasma glucose levels. Actinomycin D blocked the glucose-induced increase in IAPP expression. IAPP and insulin mRNA levels were significantly correlated over the range of glucose levels. The parallel regulation of IAPP and insulin gene expression by glucose is consistent with a role for IAPP in glucose homeostasis. Thus, under hyperglycemic conditions such as NIDDM, IAPP gene expression is likely to increase. Hence, IAPP could, by elevated local concentrations, contribute to amyloid formation and/or affect metabolism unfavorably by inhibition of insulin release and action." @default.
• W2281018049 created "2016-06-24" @default.
• W2281018049 creator A5014848806 @default.
• W2281018049 creator A5027109387 @default.
• W2281018049 creator A5089409786 @default.
• W2281018049 date "1996-12-01" @default.
• W2281018049 modified "2023-09-30" @default.
• W2281018049 title "Islet amyloid polypeptide and insulin gene expression are regulated in parallel by glucose in vivo in rats" @default.
• W2281018049 cites W1570524896 @default.
• W2281018049 cites W1605496649 @default.
• W2281018049 cites W1674418446 @default.
• W2281018049 cites W1963743323 @default.
• W2281018049 cites W1970296714 @default.
• W2281018049 cites W1974237541 @default.
• W2281018049 cites W1977638001 @default.
• W2281018049 cites W1991182327 @default.
• W2281018049 cites W2006606579 @default.
• W2281018049 cites W2009837365 @default.
• W2281018049 cites W2034109892 @default.
• W2281018049 cites W2047135359 @default.
• W2281018049 cites W2061111679 @default.
• W2281018049 cites W2064444478 @default.
• W2281018049 cites W2067820229 @default.
• W2281018049 cites W2079574762 @default.
• W2281018049 cites W2092419989 @default.
• W2281018049 cites W2094722501 @default.
• W2281018049 cites W2138932936 @default.
• W2281018049 cites W2150863408 @default.
• W2281018049 cites W2153742172 @default.
• W2281018049 cites W2158554737 @default.
• W2281018049 cites W2159404818 @default.
• W2281018049 cites W2260633481 @default.
• W2281018049 cites W4230665539 @default.
• W2281018049 doi "https://doi.org/10.1152/ajpendo.1996.271.6.e1008" @default.
• W2281018049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8997219" @default.
• W2281018049 hasPublicationYear "1996" @default.
• W2281018049 type Work @default.
• W2281018049 sameAs 2281018049 @default.
• W2281018049 citedByCount "29" @default.
• W2281018049 countsByYear W22810180492015 @default.
• W2281018049 countsByYear W22810180492016 @default.
• W2281018049 countsByYear W22810180492020 @default.
• W2281018049 countsByYear W22810180492021 @default.
• W2281018049 countsByYear W22810180492022 @default.
• W2281018049 countsByYear W22810180492023 @default.
• W2281018049 crossrefType "journal-article" @default.
• W2281018049 hasAuthorship W2281018049A5014848806 @default.
• W2281018049 hasAuthorship W2281018049A5027109387 @default.
• W2281018049 hasAuthorship W2281018049A5089409786 @default.
• W2281018049 hasConcept C104317684 @default.
• W2281018049 hasConcept C105580179 @default.
• W2281018049 hasConcept C126322002 @default.
• W2281018049 hasConcept C134018914 @default.
• W2281018049 hasConcept C150194340 @default.
• W2281018049 hasConcept C150903083 @default.
• W2281018049 hasConcept C165220095 @default.
• W2281018049 hasConcept C17093226 @default.
• W2281018049 hasConcept C185592680 @default.
• W2281018049 hasConcept C207001950 @default.
• W2281018049 hasConcept C2776828364 @default.
• W2281018049 hasConcept C2777391703 @default.
• W2281018049 hasConcept C2777633098 @default.
• W2281018049 hasConcept C2779306644 @default.
• W2281018049 hasConcept C2780705028 @default.
• W2281018049 hasConcept C3018667095 @default.
• W2281018049 hasConcept C55493867 @default.
• W2281018049 hasConcept C555293320 @default.
• W2281018049 hasConcept C59822182 @default.
• W2281018049 hasConcept C63645605 @default.
• W2281018049 hasConcept C71924100 @default.
• W2281018049 hasConcept C86803240 @default.
• W2281018049 hasConceptScore W2281018049C104317684 @default.
• W2281018049 hasConceptScore W2281018049C105580179 @default.
• W2281018049 hasConceptScore W2281018049C126322002 @default.
• W2281018049 hasConceptScore W2281018049C134018914 @default.
• W2281018049 hasConceptScore W2281018049C150194340 @default.
• W2281018049 hasConceptScore W2281018049C150903083 @default.
• W2281018049 hasConceptScore W2281018049C165220095 @default.
• W2281018049 hasConceptScore W2281018049C17093226 @default.
• W2281018049 hasConceptScore W2281018049C185592680 @default.
• W2281018049 hasConceptScore W2281018049C207001950 @default.
• W2281018049 hasConceptScore W2281018049C2776828364 @default.
• W2281018049 hasConceptScore W2281018049C2777391703 @default.
• W2281018049 hasConceptScore W2281018049C2777633098 @default.
• W2281018049 hasConceptScore W2281018049C2779306644 @default.
• W2281018049 hasConceptScore W2281018049C2780705028 @default.
• W2281018049 hasConceptScore W2281018049C3018667095 @default.
• W2281018049 hasConceptScore W2281018049C55493867 @default.
• W2281018049 hasConceptScore W2281018049C555293320 @default.
• W2281018049 hasConceptScore W2281018049C59822182 @default.
• W2281018049 hasConceptScore W2281018049C63645605 @default.
• W2281018049 hasConceptScore W2281018049C71924100 @default.
• W2281018049 hasConceptScore W2281018049C86803240 @default.
• W2281018049 hasIssue "6" @default.
• W2281018049 hasLocation W22810180491 @default.
• W2281018049 hasLocation W22810180492 @default.
• W2281018049 hasOpenAccess W2281018049 @default.
• W2281018049 hasPrimaryLocation W22810180491 @default.

• next