Matches in SemOpenAlex for { <https://semopenalex.org/work/W2281036808> ?p ?o ?g. }
- W2281036808 endingPage "343" @default.
- W2281036808 startingPage "334" @default.
- W2281036808 abstract "The posture first hypothesis suggests that under dual-task walking conditions older adults prioritize gait over cognitive task performance. Functional neural confirmation of this hypothesis, however, is lacking. Herein, we determined the functional neural correlates of the posture first hypothesis and hypothesized that the presence of neurological gait abnormalities (NGA) would moderate associations between brain activations, gait and cognitive performance. Using functional near-infrared spectroscopy we assessed changes in oxygenated hemoglobin levels in the pre-frontal cortex (PFC) during normal walk and walk while talk (WWT) conditions in a large cohort of non-demented older adults (n = 236; age = 75.5 ± 6.49 years; female = 51.7 %). NGA were defined as central (due to brain diseases) or peripheral (neuropathic gait) following a standardized neurological examination protocol. Double dissociations between brain activations and behavior emerged as a function of NGA. Higher oxygenation levels during WWT were related to better cognitive performance (estimate = 0.145; p < 0.001) but slower gait velocity (estimate = -6.336, p < 0.05) among normals. In contrast, higher oxygenation levels during WWT among individuals with peripheral NGA were associated with worse cognitive performance (estimate = -0.355; p < 0.001) but faster gait velocity (estimate = 14.855; p < 0.05). Increased activation in the PFC during locomotion may have a compensatory function that is designed to support gait among individuals with peripheral NGA." @default.
- W2281036808 created "2016-06-24" @default.
- W2281036808 creator A5002995140 @default.
- W2281036808 creator A5006028447 @default.
- W2281036808 creator A5032135106 @default.
- W2281036808 creator A5052218111 @default.
- W2281036808 creator A5060242044 @default.
- W2281036808 creator A5062618806 @default.
- W2281036808 date "2015-11-27" @default.
- W2281036808 modified "2023-10-10" @default.
- W2281036808 title "Neurological Gait Abnormalities Moderate the Functional Brain Signature of the Posture First Hypothesis" @default.
- W2281036808 cites W1681472504 @default.
- W2281036808 cites W1831557010 @default.
- W2281036808 cites W1948966723 @default.
- W2281036808 cites W1967333153 @default.
- W2281036808 cites W1981060678 @default.
- W2281036808 cites W1987292515 @default.
- W2281036808 cites W2000261287 @default.
- W2281036808 cites W2008813344 @default.
- W2281036808 cites W2012317442 @default.
- W2281036808 cites W2013468866 @default.
- W2281036808 cites W2013657375 @default.
- W2281036808 cites W2016007207 @default.
- W2281036808 cites W2029715352 @default.
- W2281036808 cites W2043561409 @default.
- W2281036808 cites W2049578680 @default.
- W2281036808 cites W2053356496 @default.
- W2281036808 cites W2054996700 @default.
- W2281036808 cites W2060073474 @default.
- W2281036808 cites W2061195971 @default.
- W2281036808 cites W2065363897 @default.
- W2281036808 cites W2078756260 @default.
- W2281036808 cites W2081614980 @default.
- W2281036808 cites W2100479414 @default.
- W2281036808 cites W2102483455 @default.
- W2281036808 cites W2102719061 @default.
- W2281036808 cites W2103991453 @default.
- W2281036808 cites W2106146649 @default.
- W2281036808 cites W2112573938 @default.
- W2281036808 cites W2118957880 @default.
- W2281036808 cites W2119015811 @default.
- W2281036808 cites W2120728836 @default.
- W2281036808 cites W2122673695 @default.
- W2281036808 cites W2124517301 @default.
- W2281036808 cites W2132524523 @default.
- W2281036808 cites W2139581313 @default.
- W2281036808 cites W2143885282 @default.
- W2281036808 cites W2148895235 @default.
- W2281036808 cites W2148984341 @default.
- W2281036808 cites W2149467862 @default.
- W2281036808 cites W2153474936 @default.
- W2281036808 cites W2155338229 @default.
- W2281036808 cites W2159296038 @default.
- W2281036808 cites W2160357034 @default.
- W2281036808 cites W2164017563 @default.
- W2281036808 cites W2165201535 @default.
- W2281036808 cites W2167123626 @default.
- W2281036808 cites W2262488289 @default.
- W2281036808 cites W4237919253 @default.
- W2281036808 cites W4251404648 @default.
- W2281036808 cites W4376849352 @default.
- W2281036808 doi "https://doi.org/10.1007/s10548-015-0465-z" @default.
- W2281036808 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4755880" @default.
- W2281036808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26613725" @default.
- W2281036808 hasPublicationYear "2015" @default.
- W2281036808 type Work @default.
- W2281036808 sameAs 2281036808 @default.
- W2281036808 citedByCount "82" @default.
- W2281036808 countsByYear W22810368082016 @default.
- W2281036808 countsByYear W22810368082017 @default.
- W2281036808 countsByYear W22810368082018 @default.
- W2281036808 countsByYear W22810368082019 @default.
- W2281036808 countsByYear W22810368082020 @default.
- W2281036808 countsByYear W22810368082021 @default.
- W2281036808 countsByYear W22810368082022 @default.
- W2281036808 countsByYear W22810368082023 @default.
- W2281036808 crossrefType "journal-article" @default.
- W2281036808 hasAuthorship W2281036808A5002995140 @default.
- W2281036808 hasAuthorship W2281036808A5006028447 @default.
- W2281036808 hasAuthorship W2281036808A5032135106 @default.
- W2281036808 hasAuthorship W2281036808A5052218111 @default.
- W2281036808 hasAuthorship W2281036808A5060242044 @default.
- W2281036808 hasAuthorship W2281036808A5062618806 @default.
- W2281036808 hasBestOaLocation W22810368082 @default.
- W2281036808 hasConcept C119653847 @default.
- W2281036808 hasConcept C126322002 @default.
- W2281036808 hasConcept C129564537 @default.
- W2281036808 hasConcept C130796691 @default.
- W2281036808 hasConcept C151800584 @default.
- W2281036808 hasConcept C15744967 @default.
- W2281036808 hasConcept C16568411 @default.
- W2281036808 hasConcept C169760540 @default.
- W2281036808 hasConcept C169900460 @default.
- W2281036808 hasConcept C185711340 @default.
- W2281036808 hasConcept C2781195155 @default.
- W2281036808 hasConcept C46762472 @default.
- W2281036808 hasConcept C71924100 @default.
- W2281036808 hasConcept C72563966 @default.