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- W2281102411 endingPage "247" @default.
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- W2281102411 abstract "Vancomycin is a first-line agent in the treatment of serious Gram-positive infections in the neonatal population. The published evidence on vancomycin toxicity in neonates is limited. This review summarizes preclinical studies and clinical trials describing vancomycin toxicity. We discuss proposed pathophysiology and summarize evidence supporting dose-response relationships, genetic and environmental determinants, and consider future research required to further define vancomycin toxicity.Current dosing regimens for vancomycin result in subtherapeutic levels in a large proportion of patients. Higher daily doses have been proposed, which have led to concerns regarding increased toxicity. Nephrotoxicity occurs in 1-9% of neonates receiving currently recommended doses. The incidence is highest in those receiving concomitant nephrotoxic drugs. Vancomycin-associated ototoxicity is rare in patients of all ages. Exposure-toxicity relationships in relation to nephrotoxicity and ototoxicity have not been clearly defined in neonates receiving vancomycin.Current evidence supports the favourable safety profile of vancomycin in neonates. Further studies that address safety concerns relating to high-dose intermittent dosing regimens are needed. Such studies must include robust and standardized definitions of renal and hearing impairment, and include follow-up of sufficient length to establish the long-term implications of experimental findings." @default.
- W2281102411 created "2016-06-24" @default.
- W2281102411 creator A5006600914 @default.
- W2281102411 creator A5016489221 @default.
- W2281102411 creator A5037577857 @default.
- W2281102411 creator A5066353178 @default.
- W2281102411 date "2016-06-01" @default.
- W2281102411 modified "2023-10-10" @default.
- W2281102411 title "Vancomycin toxicity in neonates" @default.
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- W2281102411 doi "https://doi.org/10.1097/qco.0000000000000263" @default.
- W2281102411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26895572" @default.