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- W2281283345 abstract "To evaluate whether initial levels of hCG in pregnant patients after an IVF-ICSI cycle is related with development of preeclampsia. Retrospective case-control study. IVF and obstetric records of 417 patients who had a live birth after IVF from 2005 to 2012 were evaluated. Serum beta-hCG levels on day 12 and 14 after embryo transfer were compared between patients who were treated with ICSI and fresh or frozen/thawed embryo transfer cycle and had a singleton live birth that was complicated with preeclampsia or not. A total number 168 patients were included into the analysis. In 32 patients, hCG levels were measured other than day 12 or 14 and were excluded from the study. In 136 patients day 12 and day14 hCG levels were measured and included to the study. Twenty-five (18%) patients had preeclamsia. Demographic data of patients were comparable between each group. Day 12 and day 14 beta hCG values were significantly lower in preeclampsia group (137, 17 ± 72,0 IU/l and 254.1± 158,7 IU/l, respectively) as compared to control group (205,1 ± 99,5 and 457.5 ± 267,3 IU/l, respectively) (p=0.001 and p=0.003, respectively). Initial plasma levels of hCG were inversely correlated with development of preeclampsia in pregnancies following embryo transfer. Our results support the theory of impaired invasion of trophoblasts and abnormal placentation in the main pathophysiology of preeclampsia." @default.
- W2281283345 created "2016-06-24" @default.
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- W2281283345 date "2015-09-01" @default.
- W2281283345 modified "2023-10-16" @default.
- W2281283345 title "The relationship between initial HCG levels and development of preeclampsia in pregnancies following in vitro fertilization" @default.
- W2281283345 doi "https://doi.org/10.1016/j.fertnstert.2015.07.1093" @default.
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