Matches in SemOpenAlex for { <https://semopenalex.org/work/W2281291981> ?p ?o ?g. }
- W2281291981 abstract "The cardioprotective inducible enzyme heme oxygenase-1 (HO-1) degrades prooxidant heme into equimolar quantities of carbon monoxide, biliverdin, and iron. We hypothesized that HO-1 mediates cardiac protection, at least in part, by regulating mitochondrial quality control. We treated WT and HO-1 transgenic mice with the known mitochondrial toxin, doxorubicin (DOX). Relative to WT mice, mice globally overexpressing human HO-1 were protected from DOX-induced dilated cardiomyopathy, cardiac cytoarchitectural derangement, and infiltration of CD11b+ mononuclear phagocytes. Cardiac-specific overexpression of HO-1 ameliorated DOX-mediated dilation of the sarcoplasmic reticulum as well as mitochondrial disorganization in the form of mitochondrial fragmentation and increased numbers of damaged mitochondria in autophagic vacuoles. HO-1 overexpression promotes mitochondrial biogenesis by upregulating protein expression of NRF1, PGC1α, and TFAM, which was inhibited in WT animals treated with DOX. Concomitantly, HO-1 overexpression inhibited the upregulation of the mitochondrial fission mediator Fis1 and resulted in increased expression of the fusion mediators, Mfn1 and Mfn2. It also prevented dynamic changes in the levels of key mediators of the mitophagy pathway, PINK1 and parkin. Therefore, these findings suggest that HO-1 has a novel role in protecting the heart from oxidative injury by regulating mitochondrial quality control." @default.
- W2281291981 created "2016-06-24" @default.
- W2281291981 creator A5003832053 @default.
- W2281291981 creator A5013428111 @default.
- W2281291981 creator A5016604815 @default.
- W2281291981 creator A5021821722 @default.
- W2281291981 creator A5032021083 @default.
- W2281291981 creator A5034107817 @default.
- W2281291981 creator A5054171080 @default.
- W2281291981 creator A5054399650 @default.
- W2281291981 creator A5062545659 @default.
- W2281291981 creator A5066336399 @default.
- W2281291981 creator A5070009351 @default.
- W2281291981 creator A5086257394 @default.
- W2281291981 date "2016-02-25" @default.
- W2281291981 modified "2023-10-10" @default.
- W2281291981 title "Heme oxygenase-1 regulates mitochondrial quality control in the heart" @default.
- W2281291981 cites W1560492457 @default.
- W2281291981 cites W1586487499 @default.
- W2281291981 cites W1655162787 @default.
- W2281291981 cites W1963874479 @default.
- W2281291981 cites W1966582616 @default.
- W2281291981 cites W1968791438 @default.
- W2281291981 cites W1969072747 @default.
- W2281291981 cites W1970436894 @default.
- W2281291981 cites W1973749301 @default.
- W2281291981 cites W1974605412 @default.
- W2281291981 cites W1981104741 @default.
- W2281291981 cites W1983715141 @default.
- W2281291981 cites W1985384678 @default.
- W2281291981 cites W1986575224 @default.
- W2281291981 cites W1987845572 @default.
- W2281291981 cites W1992780073 @default.
- W2281291981 cites W1998990808 @default.
- W2281291981 cites W1999793372 @default.
- W2281291981 cites W2001019228 @default.
- W2281291981 cites W2008374272 @default.
- W2281291981 cites W2009533247 @default.
- W2281291981 cites W2009909952 @default.
- W2281291981 cites W2011247976 @default.
- W2281291981 cites W2011348831 @default.
- W2281291981 cites W2020062408 @default.
- W2281291981 cites W2021129026 @default.
- W2281291981 cites W2024314608 @default.
- W2281291981 cites W2026660662 @default.
- W2281291981 cites W2028778467 @default.
- W2281291981 cites W2029059005 @default.
- W2281291981 cites W2029542561 @default.
- W2281291981 cites W2032048503 @default.
- W2281291981 cites W2032079709 @default.
- W2281291981 cites W2033066735 @default.
- W2281291981 cites W2034087770 @default.
- W2281291981 cites W2039356011 @default.
- W2281291981 cites W2040913240 @default.
- W2281291981 cites W2041255615 @default.
- W2281291981 cites W2044929466 @default.
- W2281291981 cites W20486147 @default.
- W2281291981 cites W2048935707 @default.
- W2281291981 cites W2049636133 @default.
- W2281291981 cites W2052867135 @default.
- W2281291981 cites W2057340956 @default.
- W2281291981 cites W2058354810 @default.
- W2281291981 cites W2058653820 @default.
- W2281291981 cites W2062145087 @default.
- W2281291981 cites W2063671731 @default.
- W2281291981 cites W2065371404 @default.
- W2281291981 cites W2067714284 @default.
- W2281291981 cites W2068298617 @default.
- W2281291981 cites W2073790538 @default.
- W2281291981 cites W2075058886 @default.
- W2281291981 cites W207786595 @default.
- W2281291981 cites W2081360068 @default.
- W2281291981 cites W2082802659 @default.
- W2281291981 cites W2084304742 @default.
- W2281291981 cites W2088002295 @default.
- W2281291981 cites W2092847166 @default.
- W2281291981 cites W2093057466 @default.
- W2281291981 cites W2097704104 @default.
- W2281291981 cites W2099774211 @default.
- W2281291981 cites W2105404724 @default.
- W2281291981 cites W2105641380 @default.
- W2281291981 cites W2106444069 @default.
- W2281291981 cites W2112885253 @default.
- W2281291981 cites W2113515610 @default.
- W2281291981 cites W2113999599 @default.
- W2281291981 cites W2116562304 @default.
- W2281291981 cites W2123115740 @default.
- W2281291981 cites W2124267728 @default.
- W2281291981 cites W2126337135 @default.
- W2281291981 cites W2129971042 @default.
- W2281291981 cites W2137179625 @default.
- W2281291981 cites W2138311396 @default.
- W2281291981 cites W2139927762 @default.
- W2281291981 cites W2140182328 @default.
- W2281291981 cites W2144174954 @default.
- W2281291981 cites W2147551208 @default.
- W2281291981 cites W2149301933 @default.
- W2281291981 cites W2152674951 @default.
- W2281291981 cites W2154485147 @default.
- W2281291981 cites W2154887758 @default.