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• W2281330998 abstract "Abstract Ectopic DNA binding by transcription factors and other DNA binding proteins can be detrimental to cellular functions and ultimately to organismal fitness. The frequency of protein-DNA binding at non-functional sites depends on the global composition of a genome with respect to all possible short motifs, or k -mer words. To determine whether weak yet ubiquitous protein-DNA interactions could exert significant evolutionary pressures on genomes, we correlate in vitro measurements of binding strengths on all 8-mer words from a large collection of transcription factors, in several different species, against their relative genomic frequencies. Our analysis reveals a clear signal of purifying selection to reduce the large number of weak binding sites genome-wide. This evolutionary process, which we call global selection , has a detectable hallmark in that similar words experience similar evolutionary pressure, a consequence of the biophysics of protein-DNA binding. By analyzing a large collection of genomes, we show that global selection exists in all domains of life, and operates through tiny selective steps, maintaining genomic binding landscapes over long evolutionary timescales." @default.
• W2281330998 created "2016-06-24" @default.
• W2281330998 creator A5022358779 @default.
• W2281330998 creator A5031609341 @default.
• W2281330998 date "2016-02-23" @default.
• W2281330998 modified "2023-10-15" @default.
• W2281330998 title "Natural selection driven by DNA binding proteins shapes genome-wide motif statistics" @default.
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• W2281330998 doi "https://doi.org/10.1101/041145" @default.
• W2281330998 hasPublicationYear "2016" @default.
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