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- W2281361473 abstract "Patients with systemic sclerosis (SSc) are at risk for developing pulmonary hypertension, which is associated with a poor prognosis.The aim of this study was to evaluate the comparison between risk factors and clinical parameters of exercise-induced increase in mean PAP in small group patients with SSc.We selected 19 patients with SSc (age 54 ± 11 years, all female) with normal resting mean PAP (17.2 ± 3.9 mm Hg) who underwent graded bicycle supine exercise right heart catheterization. Pulmonary artery systolic pressure, cardiac output, and other were estimated invasively. Cutoff values of mean PAP ≥30 mm Hg at peak exercise were considered exercise-induced pulmonary hypertension. The risk of PAH development was calculated by DETECT PAH risk calculator. Level of uric acid also was measured in all pts.Only 10 from 19 pts had a risk factors by DETECT calculator, but we didn't found PH at rest RHC. 9 (47%) patients showed a significant exercise-induced pulmonary hypertension, 7 hadn't changes in pressure follow exercises. 3 pts were excluded with low exercise capacity. We found that patients with EI-PH had significantly higher calculating level of PAH risk in DETECT scale than without (315 ± 20 vs 287 ± 24, p<0,05). Also we found that level of biomarkers were higher in group with EI-PH (uric acid 286±83 vs 182±58, p<0,05)Conclusion: exercise-induced increase in mean PAP occurs in almost one-half of patients with SSc with normal resting PASP. Detection of interrelation between EI-PH and risk-score and higher biomarkers level could testify that pts without PH now probably will develop it in nearest future and demand the early therapy intervention." @default.
- W2281361473 created "2016-06-24" @default.
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- W2281361473 date "2014-09-01" @default.
- W2281361473 modified "2023-09-24" @default.
- W2281361473 title "Exercise-induced pulmonary hypertension in patients with systemic sclerosis: Pilot-study" @default.
- W2281361473 hasPublicationYear "2014" @default.
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