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- W2281383413 endingPage "1788" @default.
- W2281383413 startingPage "1770" @default.
- W2281383413 abstract "The hypothesis that dietary (poly)phenols promote well‐being by improving chronic disease‐risk biomarkers, such as endothelial dysfunction, chronic inflammation and plasma uric acid, is the subject of intense current research, involving human interventions studies, animal models and in vitro mechanistic work. The original claim that benefits were due to the direct antioxidant properties of (poly)phenols has been mostly superseded by detailed mechanistic studies on specific molecular targets. Nevertheless, many proposed mechanisms in vivo and in vitro are due to modulation of oxidative processes, often involving binding to specific proteins and effects on cell signalling. We review the molecular mechanisms for 3 actions of (poly)phenols on oxidative processes where there is evidence in vivo from human intervention or animal studies. (1) Effects of (poly) phenols on pathways of chronic inflammation leading to prevention of some of the damaging effects associated with the metabolic syndrome. (2) Interaction of (poly)phenols with endothelial cells and smooth muscle cells, leading to effects on blood pressure and endothelial dysfunction, and consequent reduction in cardiovascular disease risk. (3) The inhibition of xanthine oxidoreductase leading to modulation of intracellular superoxide and plasma uric acid, a risk factor for developing type 2 diabetes." @default.
- W2281383413 created "2016-06-24" @default.
- W2281383413 creator A5020427938 @default.
- W2281383413 creator A5063714054 @default.
- W2281383413 date "2016-03-29" @default.
- W2281383413 modified "2023-10-17" @default.
- W2281383413 title "At the interface of antioxidant signalling and cellular function: Key polyphenol effects" @default.
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