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- W2281396661 abstract "evaluate differences between the standard and the new design a two way repeated measurement ANOVA analysis was performed. RESULTS: The FE simulations for the OPRA and the ISP implants showed high stress concentration in the proximal region decreasing in the distal direction to values below physiological levels as compared with the intact bone. The stresses around the new design were more uniformly distributed along the cortex and resembled better the intact case. Consequently, the bone failure risk was reduced as compared to the OPRA and the ISP implants. The adaptive bone remodeling simulations showed high bone resorption around distal parts of the OPRA and the ISP implants in the distal end of the femur - zones 1 and 7 (on average - 42% ISP to -51% OPRA after 60 months) (Fig.4). The experimental measurements showed overall changes in cortical strains after insertion of the standard titanium screw fixation compared with the new designed implant for single-leg stance and toe-off (ANOVA, p<0.03). The strains measured for the new design were much closer to the values obtained for the intact bones, as compared to the standard screw implant (Fig.5)." @default.
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- W2281396661 date "2012-02-04" @default.
- W2281396661 modified "2023-09-27" @default.
- W2281396661 title "Pre-clinical development of a new osseointegrated fixation implant for amputated patients designed to reduce bone failure risk and periprosthetic bone loss" @default.
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