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- W2281417782 abstract "Cryptococcus neoformans and C. gattii are fungal pathogens that cause life-threatening disease. These fungi commonly enter their host via inhalation into the lungs where they encounter resident phagocytes, including macrophages and dendritic cells, whose response has a pronounced impact on the outcome of disease. Cryptococcus has complex interactions with the resident and infiltrating innate immune cells that, ideally, result in destruction of the yeast. These phagocytic cells have pattern recognition receptors that allow recognition of specific cryptococcal cell wall and capsule components. However, Cryptococcus possesses several virulence factors including a polysaccharide capsule, melanin production and secretion of various enzymes that aid in evasion of the immune system or enhance its ability to thrive within the phagocyte. This review focuses on the intricate interactions between the cryptococci and innate phagocytic cells including discussion of manipulation and evasion strategies used by Cryptococcus, anti-cryptococcal responses by the phagocytes and approaches for targeting phagocytes for the development of novel immunotherapeutics." @default.
- W2281417782 created "2016-06-24" @default.
- W2281417782 creator A5044294009 @default.
- W2281417782 creator A5050851557 @default.
- W2281417782 creator A5068233995 @default.
- W2281417782 creator A5074919497 @default.
- W2281417782 date "2016-02-09" @default.
- W2281417782 modified "2023-10-02" @default.
- W2281417782 title "Cryptococcus and Phagocytes: Complex Interactions that Influence Disease Outcome" @default.
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