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- W2281424227 abstract "Previous studies have suggested the possible involvement of oral contraceptives (OC) in enhanced red blood cell production (erythropoiesis). The present study attmepts to determine the effect of OC use on iron storage, as measured by serum ferritin, and on erythropoeitic activity in Malaysians. Health women of the 3 major Malaysian ethnic groups (Malays, Chinese, and Indians), all of whom were low-dose OC users, served as the study group. The findings confirm previous reports that serum iron levels are significantly increased in women taking OCs. Serum ferritin, a better measure of total body iron stores, dropped during the 1st 1-12 months of OC therapy. The drop was most pronounced at 4-6 months. However, by 1 or 2 years, the serum ferritin levels were comparable to those of the control group. Coinciding with the drop in serum ferritin was an increase in hemoglobin synthesis and erythropoiesis. These findings suggest that the initial drop in serum ferritin may be attributed to increased mobilization and utilization of iron as a result of increased erythropoiesis. This enhanced red blood cell production appears to be a consequence of OC therapy. After the 1st year, a new equilibrium is reached, at which the mean hemoglobin level, as well as total white blood cell and platelet count, is higher in OC users than in controls. Such changes have been shown to affect the flow properties of blood; further studies are needed to determine if these factors bear on the thromboembolic complications of OC use." @default.
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- W2281424227 date "1983-01-01" @default.
- W2281424227 modified "2023-09-24" @default.
- W2281424227 title "The effect of oral contraceptives in Malaysians: 1. iron metabolism and erythropoiesis." @default.
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